Gallstone disease is associated with more severe liver damage in patients with non-alcoholic fatty liver disease
| Autor: | Anna Ludovica Fracanzani, Antonio Grieco, Consuelo Cefalo, Maurizio Russello, Luca Miele, Luca Valenti, Alessandro Bellia, Giulio Marchesini, C. Masetti, Cristina Bertelli, Silvia Fargion |
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| Přispěvatelé: | AL Fracanzani, L Valenti, M Russello, L Miele, C Bertelli, A Bellia, C Masetti, A Grieco, G Marchesini Reggiani, S Fargion |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Epidemiology lcsh:Medicine Nonalcoholic Steatohepatitis Gallstones Gastroenterology Severity of Illness Index TYPE 2 DIABETES Liver disease Endocrinology Non-alcoholic Fatty Liver Disease Risk Factors Cholelithiasis Nonalcoholic fatty liver disease Prevalence lcsh:Science Abdominal obesity Multidisciplinary medicine.diagnostic_test Liver Diseases Fatty liver Age Factors Middle Aged Liver Liver biopsy Obesity Abdominal Medicine Female medicine.symptom Biliary Disorders Research Article Adult medicine.medical_specialty Clinical Research Design Gastroenterology and Hepatology Diabetes Complications Insulin resistance Sex Factors NAFLD Internal medicine Diabetes mellitus medicine Animals Humans Obesity Biology GALLSTONE Aged Retrospective Studies Nutrition Diabetic Endocrinology Population Biology business.industry Settore MED/09 - MEDICINA INTERNA lcsh:R Diabetes Mellitus Type 2 medicine.disease Fatty Liver Glucose LIVER ENZYMES Metabolic Disorders lcsh:Q Metabolic syndrome Insulin Resistance business |
| Zdroj: | PLoS ONE, Vol 7, Iss 7, p e41183 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GD) are both highly prevalent in the general population and associated with obesity and insulin resistance. We aimed to evaluate the prevalence of GD in a cross sectional study of NAFLD patients and to define whether the presence of GD is associated with diabetes and predicts more severe liver disease. Methodology/Principal Findings We merged databases of four Liver Units, comprising 524 consecutive biopsy-proven NAFLD (373 males) observed between January 2003 and June 2010. GD was diagnosed in 108 (20%), and 313 cases (60%) were classified by liver biopsy as nonalcoholic steatohepatitis (NASH). The GD subgroup was characterized by a significantly higher prevalence of females, prediabetes/diabetes, abdominal obesity and metabolic syndrome, older age, higher BMI, fasting glucose, HOMA-IR and lower ALT. The prevalence of GD progressively increased with advancing fibrosis and with the severity of necroinflammatory activity (p for trend = 0.0001 and = 0.01, respectively), without differences in the severity of steatosis. At multivariate analysis GD was associated with female gender (OR 1.37, 95% CI 1.04–1.8), age (OR 1.027, 95% CI1.003–1.05), fasting glucose (OR 1.21, 95% CI 1.10–1.33) and NASH (OR 1.40,95% CI 1.06–1.89), whereas ALT levels were associated with a lower GD risk (OR 0.98, 95% CI 0.97–0.99). When subjects with cirrhosis were excluded from analysis, the association between GD and fasting glucose, female gender, and NASH was maintained. Conclusion Patients with NAFLD have a high prevalence of GD, which characterizes subjects with altered glucose regulation and more advanced liver disease. |
| Databáze: | OpenAIRE |
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