Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice
| Autor: | Wen-Tsong Hsieh, Chen-Si Lin, Geng-Ruei Chang, Chuen-Fu Lin, Ching-Fen Wu, Lan-Szu Chou, Chen-Yung Kao, Wei-Li Lin, Huei-Jyuan Liao, Tzu-Chun Lin, Jen-Wei Lin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty obesity renal injury 030209 endocrinology & metabolism Bioengineering Type 2 diabetes TP1-1185 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Nonalcoholic fatty liver disease medicine Chemical Engineering (miscellaneous) curcumin QD1-999 fatty liver chemistry.chemical_classification Triglyceride biology business.industry Process Chemistry and Technology Glutathione peroxidase Chemical technology Fatty liver Glucose transporter nutritional and metabolic diseases medicine.disease Chemistry 030104 developmental biology Endocrinology chemistry glucose intolerance biology.protein chromium business GLUT4 |
| Zdroj: | Processes, Vol 9, Iss 1132, p 1132 (2021) Processes Volume 9 Issue 7 |
| ISSN: | 2227-9717 |
| Popis: | Obesity-associated hyperglycemia underlies insulin resistance, glucose intolerance, and related metabolic disorders including type 2 diabetes, renal damage, and nonalcoholic fatty liver disease. Turmeric root is commonly used in Asia, and curcumin, one of its pharmacological components, can play a role in preventing and treating certain chronic physiological disorders. Accordingly, this study examined how high-fat diet (HFD)-induced hyperglycemia and hyperlipidemia are reduced by curcumin through changes in fatty liver scores, chromium distribution, and renal injury in mice. Relative to the control group, also fed an HFD, the curcumin group weighed less and had smaller adipocytes it also had lower daily food efficiency, blood urea nitrogen and creatinine levels, serum alanine aminotransferase and aspartate aminotransferase levels, serum and hepatic triglyceride levels, and hepatic lipid regulation marker expression. The curcumin-treated obese group exhibited significantly lower fasting blood glucose, was less glucose intolerant, had higher Akt phosphorylation and glucose transporter 4 (GLUT4) expression, and had greater serum insulin levels. Moreover, the group showed renal damage with lower TNF-α expression along with more numerous renal antioxidative enzymes that included superoxide dismutase, glutathione peroxidase, and catalase. The liver histology of the curcumin-treated obese mice showed superior lipid infiltration and fewer FASN and PNPLA3 proteins in comparison with the control mice. Curcumin contributed to creating a positive chromium balance by decreasing the amount of chromium lost through urine, leading to the chromium mobilization needed to mitigate hyperglycemia. Thus, the results suggest that curcumin prevents HFD-induced glucose intolerance, kidney injury, and nonalcoholic fatty liver disease. |
| Databáze: | OpenAIRE |
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