Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
| Autor: | Roberto Grosso, Elena Benito, Ana I. Carbajo-Gordillo, M. Gracia García-Martín, Víctor Perez-Puyana, Pablo Sánchez-Cid, M.-Violante de-Paz |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
amoxicillin
vonoprazan mucoadhesive polymers super-porous hydrogels Organic Chemistry Helicobacter pylori General Medicine bioorthogonal chemistry Catalysis Computer Science Applications Inorganic Chemistry guar gum semi-IPN Physical and Theoretical Chemistry gastroretentive DDS Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences Volume 24 Issue 3 Pages: 2281 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24032281 |
| Popis: | An increase in resistance to key antibiotics has made the need for novel treatments for the gastric colonization of Helicobacter pylori (H. pylori) a matter of the utmost urgency. Recent studies tackling this topic have focused either on the discovery of new compounds to ameliorate therapeutic regimes (such as vonoprazan) or the synthesis of gastroretentive drug delivery systems (GRDDSs) to improve the pharmacokinetics of oral formulations. The use of semi-interpenetrating polymer networks (semi-IPNs) that can act as super-porous hydrogels for this purpose is proposed in the present work, specifically those displaying low ecological footprint, easy synthesis, self-floating properties, high encapsulation efficiency for drugs such as amoxicillin (AMOX), great mucoadhesiveness, and optimal mechanical strength when exposed to stomach-like fluids. To achieve such systems, biodegradable synthetic copolymers containing acid-labile monomers were prepared and interpenetrated with guar gum (GG) in a one-pot polymerization process based on thiol-ene click reactions. The resulting matrices were characterized by SEM, GPC, TGA, NMR, and rheology studies, and the acidic hydrolysis of the acid-sensitive polymers was also studied. Results confirm that some of the obtained matrices are expected to perform optimally as GRDDSs for the sustained release of active pharmaceutical ingredients at the gastrointestinal level, being a priori facilitated by its disaggregation. Therefore, the optimal performance of these systems is assessed by varying the molar ratio of the labile monomer in the matrices. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |