5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex
| Autor: | H. Hüring, Thomas J. Feuerstein, Carl Hermann Lücking, G. B. Landwehrmeyer, V. Van Velthoven |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Agonist Serotonin medicine.medical_specialty GABA Agents medicine.drug_class Central nervous system Nipecotic Acids Tetrodotoxin In Vitro Techniques Biology GABA Antagonists chemistry.chemical_compound Species Specificity Internal medicine Oximes medicine Animals Humans Neurotransmitter Receptor 3-Mercaptopropionic Acid gamma-Aminobutyric Acid Cerebral Cortex Neocortex Sumatriptan General Neuroscience Nicotinic Acids Middle Aged Receptor antagonist Electric Stimulation Serotonin Receptor Agonists Endocrinology medicine.anatomical_structure nervous system chemistry Receptors Serotonin GABAergic Female 5-HT1 receptor Rabbits Serotonin Antagonists |
| Zdroj: | Neuroscience Letters. 209:210-214 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(96)12637-9 |
| Popis: | Both human and rabbit brain contain the 5-hydroxytryptamine (5-HT)1D subtype of 5-HT1 receptors. We studied the effects of 5-HT1D receptor stimulation on neocortical [3H]γ-aminobutyric acid (GABA) release from GABAergic neurons in these species. The 5-HT1D receptor agonist sumatriptan depressed [3H]GABA release in human neocortex and the 5-HT1 receptor antagonist metitepin prevented this depression with potencies suggesting mediation by 5-HT1D-like receptors. In rabbit neocortex, however, 5-HT1D agonists did not affect the release of [3H]GABA. Since 5-HT and GABA seem to function antagonistically in anxiety disorders their neocortical interaction may be (patho)physiologically relevant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect