Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity: results of a prospective multicenter study of 166 patients
| Autor: | Gregor Goldner, Regina Pötzi, Stefan Glocker, Richard Pötter, Jochen Reibenwein, Michael Bamberg, Birgit Tomicek, Frank B. Zimmermann, Michael Molls, Hans Geinitz, Gerd Becker, Natascha Wachter-Gerstner, Stefan Wachter, Horst Feldmann |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Rectum Proctoscopy Severity of Illness Index Vienna Rectoscopy Score Prostate cancer Multicenter trial medicine Humans Radiology Nuclear Medicine and imaging Proctitis External beam radiotherapy Prospective Studies Intestinal Mucosa Radiation Injuries Aged Aged 80 and over Radiation medicine.diagnostic_test business.industry Prostatic Neoplasms Radiotherapy Dosage Middle Aged medicine.disease Surgery Radiation therapy medicine.anatomical_structure Oncology Feasibility Studies Radiology business |
| Zdroj: | International journal of radiation oncology, biology, physics. 67(1) |
| ISSN: | 0360-3016 |
| Popis: | To evaluate the Vienna Rectoscopy Score (VRS) as a feasible and effective tool for detecting and classifying pathologic changes in the rectal mucosa after radiotherapy (RT) for prostate cancer, and, also, to correlate its findings with the European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) score for late rectal toxicity.A total of 486 patients with localized prostate cancer underwent external-beam RT up to 70 or 74 Gy within an Austrian-German prospective multicenter trial. In 166 patients, voluntary rectal sigmoidoscopy was performed before and at 12 and/or 24 months after RT. Pathologic findings such as telangiectasia, congested mucosa, and ulcers were graded (Grades 0-3) and summarized according to the VRS. Late rectal side effects (EORTC/RTOG) were documented and correlated with the corresponding VRS.Before RT, 99% had a VRS score of 0. The median follow-up was 40 months. Overall, a late rectal side effects grade or score 1-3 was detected in 43% by EORTC/RTOG compared with 68% by VRS (p0.05). Grades 0, 1, 2, and 3 late rectal side effects were found using EORTC/RTOG in 57%, 11%, 28%, and 3%, respectively; the corresponding percentages were 32%, 22%, 32%, and 14% for a VRS of 0, 1, 2, and 3, respectively. A significant coherence between the VRS and EORTC/RTOG was found (p0.01).The VRS is a feasible and effective tool for describing and classifying pathologic findings in the rectal mucosa after RT within a multicenter trial. The VRS and EORTC/RTOG showed a high coherence. However the VRS was significantly more sensitive. |
| Databáze: | OpenAIRE |
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