Subchronic toxicity studies of 3-Methyl-1- butanol and 2-Methyl-1-propanol in rats
| Autor: | M Kayser, K. Deckardt, K. Küttler, H.-J. Klimisch, K Schilling |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Butanols Health Toxicology and Mutagenesis Mean corpuscular hemoglobin Pharmacology Toxicology 03 medical and health sciences chemistry.chemical_compound Pentanols 0302 clinical medicine Water Supply Oral administration medicine Animals Palatability Rats Wistar Mean corpuscular volume 030102 biochemistry & molecular biology medicine.diagnostic_test Butanol Body Weight General Medicine Blood Cell Count Rats Subchronic toxicity chemistry 030220 oncology & carcinogenesis Toxicity Solvents Female Histopathology Blood Chemical Analysis |
| Zdroj: | Human & Experimental Toxicology. 16:722-726 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/096032719701601205 |
| Popis: | 1 90-day subchronic toxicity studies with 3-methyl-1- butanol (MEB) and 2-methyl-1-propanol (MEP) were performed on rats to evaluate the toxicological profile of the compounds under conditions of drinking water studies, to identify the potential target organs, and to determine no-observable-adverse-effect-levels (NOAELs) respective of the substances. The test substances were administered to groups of 10 male and 10 female Wistar rats in drinking water at concentrations of 0, 1000 p.p.m. (about 80 mg/kg/d), 4000 p.p.m. (about 340 mg/kg/d) and 16 000 p.p.m. (about 1250 and 1450 mg/kg/d of MEB and MEP respectively). 2 16 000 p.p.m. was found to be the maximal concentra tion for both alcohols applicable to rats in drinking water. Higher concentrations had an influence on palatability and could thus not be tested in drinking water studies. 3 At 16 000 p.p.m. MEB a marginal increase in the red blood cell count as well as a slight decrease in the mean corpuscular volume and the mean corpuscular hemo globin content was observed in males only. These changes are considered to be treatment-related, although the toxicological significance of these find ings is unclear. No other substance-related effects were found on body weight (b.w.), mortality, various parameters of clinical chemistry, organ weights, gross pathology and histopathology. 4000 p.p.m. MEB did not cause any substance-induced changes. Therefore, the NOAEL of MEB was defined as 4000 p.p.m. for male and 16 000 p.p.m. for female rats under condi tions of oral application via drinking water. 4 MEP concentrations up to and including 16 000 p.p.m. did not induce any signs of toxicity and were therefore defined as the NOAEL respective of this substance for rats under conditions of drinking water application. |
| Databáze: | OpenAIRE |
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