Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets
| Autor: | Imjak Jeon, Tiziana Gilli, Gabriele Betz |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Materials science
lcsh:QD71-142 Hydroxypropyl cellulose roll compaction hydroxypropyl cellulose Compaction lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering Viscosity grade General Biochemistry Genetics and Molecular Biology Preparation method Matrix (chemical analysis) lcsh:Pharmacy and materia medica Dry granulation chemistry.chemical_compound Granulation chemistry matrix tablet Drug release Particle size General Pharmacology Toxicology and Pharmaceutics Composite material sustained release Research Article |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences Journal of Pharmacy and Bioallied Sciences, Vol 3, Iss 2, Pp 213-220 (2011) |
| ISSN: | 0975-7406 |
| Popis: | Roll compaction was applied for the preparation of hydroxypropyl cellulose (HPC)-based sustained-release matrix tablets. Matrix tablets made via roll compaction exhibited higher dosage uniformity and faster drug release than direct-compacted tablets. HPC viscosity grade, roll pressure, and milling speed affected tablet properties significantly. Roll compaction seems to be an adequate granulation method for the preparation of HPC-based matrix tablets due to the simplicity of the process, less handling difficulty from HPC tackiness as well as easier particle size targeting. Selecting the optimum ratio of plastic excipients and the particle size of starting materials can however be critical issues in this method. |
| Databáze: | OpenAIRE |
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