Acute kidney injury criteria predict outcomes of critically ill patients
| Autor: | Constantine A. Manthous, Jianmin Tian, Fidel Barrantes, Yaw Amoateng-Adjepong, Rodrigo Vazquez |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Critical Illness Critical Care and Intensive Care Medicine Cohort Studies chemistry.chemical_compound Oliguria Internal medicine Intensive care medicine Humans Renal replacement therapy Hospital Mortality Aged Retrospective Studies Aged 80 and over Creatinine business.industry Acute kidney injury Odds ratio Acute Kidney Injury Length of Stay Middle Aged medicine.disease Prognosis Surgery Renal Replacement Therapy chemistry Female Hemodialysis medicine.symptom business Kidney disease |
| Zdroj: | Critical care medicine. 36(5) |
| ISSN: | 1530-0293 |
| Popis: | Objective: The Acute Kidney Injury Network's proposed definition for acute kidney injury (increment of serum creatinine ≥0.3 mg/dL or 50% from baseline within 48 hrs or urine output 6 hrs despite fluid resuscitation when applicable) predicts meaningful clinical outcomes. Design: Retrospective cohort study. Setting: A 350-bed community teaching hospital. Patients: The study population consisted of 471 patients with no recent history of renal replacement therapy who were admitted to the medical intensive care unit during 1 yr. Interventions: Medical records of all patients were reviewed using a data abstraction tool. Demographic information, diagnoses, risk factors for acute kidney disease, physiologic and laboratory data, and outcomes were recorded. Measurements and Main Results: Of 496 patients, 471 were not receiving renal replacement therapy in the weeks before medical intensive care unit admission; 213 had changes ≥.3 mg/dL in serum creatinine within 48 hrs and/or urine output of ≥.5 mL/kg/hr for >6 hrs. Detailed fluid challenge information was available for only 123 patients, who met acute kidney injury criteria, and three patients reversed after administration of ≥500 mL of intravenous fluid and/or blood products. All patients whose creatinine increased ≥50% also had increments ≥0.3 mg/dL. The 120 patients with acute kidney injury were older (mean ± SE: 69.3 ± 1.7 vs. 62.9 ± 1.3, p |
| Databáze: | OpenAIRE |
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