A Functional Connectivity Study to Investigate the Role of the Right Anterior Insula in Modulating Emotional Dysfunction in Borderline Personality Disorder
| Autor: | Joaquim Soler, Frederic Sampedro, Matilde Elices, Ignacio Aracil-Bolaños, Cristina Carmona I Farrés, Raymond Salvador, Edith Pomarol-Clotet, Carlos Schmidt, Juan C. Pascual, Daniel Vega |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
mindfulness
Mindfulness DERS = Difficulties in Emotion Regulation Scale psychotherapeutic response Interpersonal communication anterior insula Correlation PFC = prefrontal cortex Intervention (counseling) ROI = region of interest Medicine DBT-M = mindfulness skills training module of DBT Borderline personality disorder OFC = orbitofrontal cortex Applied Psychology Default mode network rs-fMRI = resting-state functional magnetic resonance imaging business.industry medicine.disease DMN = default mode network PCC = posterior cingulate cortex Psychiatry and Mental health mPFC = medial prefrontal cortex connectivity BSL-23=Borderline Symptom List-23 salience network DBT = dialectical behavior therapy DBT-IE = interpersonal effectiveness skills training module of DBT SN = salience network BPD = borderline personality disorder business ACC = anterior cingulated cortex rAI = right anterior insula Insula Right anterior borderline personality disorder Clinical psychology |
| Zdroj: | PSYCHOSOMATIC MEDICINE r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Universidad Europea (UEM) |
| ISSN: | 1534-7796 0033-3174 |
| Popis: | Objective Previous imaging studies in patients with borderline personality disorder (BPD) have detected functional brain dysfunctions. Mindfulness training may improve the symptoms of BPD, although the neural mechanisms involved remain poorly understood. This study had several key aims: a) to investigate the role of right anterior insula (rAI) functional connectivity in modulating baseline emotional status in BPD, b) to compare differences in connectivity changes after mindfulness training versus interpersonal effectiveness intervention, and c) to explore the correlation between longitudinal changes in imaging data and clinical indicators. Methods Thirty-eight patients with BPD underwent resting-state functional magnetic resonance imaging. Participants completed self-report clinical scales and participated in a dialectical-behavioral therapy (mindfulness versus interpersonal effectiveness modules). Changes in clinical and imaging variables were evaluated longitudinally after completion of the first 10-week sessions of psychotherapeutic intervention. Results At baseline, the rAI was strongly connected with the other salience network nodes and anticorrelated with most core nodes of the default mode network (p < .05, corrected). The functional connectivity of the rAI correlated with emotional dysregulation and deficits in mindfulness capacities (p < .05, corrected). After completion of psychotherapeutic intervention, both groups (mindfulness and interpersonal effectiveness) showed divergent posttherapy functional connectivity changes, which were in turn associated with the clinical response. Conclusions The functional connectivity of the rAI seems to play an important role in emotion dysregulation and deficits in mindfulness capacities in individuals with BPD. Psychotherapy seems to modulate this functional connectivity, leading to beneficial changes in clinical variables. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|