Metabolic and genetic markers’ associations with elevated levels of alanine aminotransferase in adolescents
| Autor: | Francisco Mendoza-Carrera, Jorge Salmerón, Victoria Valles-Sánchez, Segundo Morán-Villota, Xochitl Helga Castro-Martínez, Guadalupe Ramírez-López, Eliseo Portilla-de Buen, José Sánchez-Corona |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Genetic Markers Male 0301 basic medicine medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Chronic liver disease Gastroenterology Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Risk Factors Internal medicine medicine Humans Obesity Mexico Metabolic Syndrome biology business.industry Fatty liver Alanine Transaminase Odds ratio Prognosis medicine.disease Cross-Sectional Studies 030104 developmental biology Alanine transaminase Pediatrics Perinatology and Child Health biology.protein Female 030211 gastroenterology & hepatology Insulin Resistance Metabolic syndrome business Body mass index Follow-Up Studies |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 31:407-414 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2017-0217 |
| Popis: | Background: Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in adolescents, is a feature of metabolic syndrome (MetS). Obesity and insulin resistance (IR) are risk factors for NAFLD, as well as inflammation-related genetic markers. The relationship between metabolic or inflammation-related genetic markers and alanine aminotransferase (ALT) is not fully understood. We examined the relationship of MetS, metabolic and inflammation-related genetic markers with elevated ALT in adolescents. Methods: A total of 674 adolescents participated in a cross-sectional study in Guadalajara, Mexico. Elevated ALT (>40 IU/L), a surrogate marker of NAFLD, and MetS (International Diabetes Federation definition) were evaluated. Obesity, IR, lipids, C-reactive protein (CRP) and genetic markers (TNFA-308G>A, CRP+1444C>T, IL1RN and IL6-597/-572/-174 haplotype) were evaluated. Multivariate logistic regression was performed. Results: Elevated ALT was observed in 3% and 14.1% (total and obese, respectively) of the adolescents. Obesity (odds ratio [OR], 5.86; 95% confidence interval [95% CI], 1.16–25.89), insulin (OR, 8.51; 95% CI, 2.61–27.71), IR (OR, 9.10; 95% CI, 2.82–29.38), total cholesterol (TC) (OR, 3.67; 95% CI, 1.25–10.72), low-density lipoprotein-cholesterol (LDL-C) (OR, 3.06; 95% CI, 1.06–8.33), non-high-density lipoprotein-cholesterol (HDL-C) (OR, 3.88; 95% CI, 1.27–11.90) and IL1RN (OR, 4.64; 95% CI, 1.10–19.53) were associated with elevated ALT. Among males, ≥2 MetS criteria were associated with elevated ALT (OR, 4.22; 95% CI, 1.14–15.71). Conclusions: Obesity, insulin, IR, high TC, high LDL-C, high non-HDL-C and IL1RN polymorphism were associated with elevated ALT. Among males, ≥2 MetS criteria were associated with elevated ALT. There is an urgent need to reduce obesity and IR in adolescents to prevent NAFLD. |
| Databáze: | OpenAIRE |
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