Emotional processing in panic disorder and its subtypes: An fMRI study using emotional faces

Autor: T. Pattyn, F. Van Den Eede, Lianne Schmaal, Brenda W.J.H. Penninx, Bernard Sabbe, D.J. Veltman, L. Cassiers
Přispěvatelé: Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Anatomy and neurosciences, Amsterdam Neuroscience - Brain Imaging, APH - Digital Health
Rok vydání: 2020
Předmět:
Zdroj: Pattyn, T, Schmaal, L, Eede, F V D, Cassiers, L, Penninx, B W, Sabbe, B C G & Veltman, D J 2021, ' Emotional processing in panic disorder and its subtypes : An fMRI study using emotional faces ', Journal of Affective Disorders, vol. 287, pp. 427-432 . https://doi.org/10.1016/j.jad.2021.03.069
Journal of affective disorders
Journal of Affective Disorders, 287, 427-432. Elsevier
ISSN: 1573-2517
0165-0327
DOI: 10.1016/j.jad.2021.03.069
Popis: Background Inconsistent findings regarding the pathophysiology of panic disorder (PD) could result from clinical heterogeneity. Identifying subtypes could enhance insights into the neurobiological substrates of PD. Methods An emotional faces fMRI paradigm was used in a group of PD patients (n = 73) and healthy controls (n = 58). The overall PD group was further divided into three previously identified subtypes: a cognitive-autonomic (n = 22), an autonomic (n = 16) and an aspecific (n = 35) subtype. Differences in brain activity levels in response to emotional facial expressions between groups were examined for six regions of interests, namely the amygdala, ventromedial prefrontal cortex, anterior cingulate, fusiform gyrus, lingual gyrus and insula. Results PD patients showed lower activity in the rostral anterior cingulate in response to angry faces than healthy controls, which was mainly driven by the autonomic subtype. No significant differences were found in other brain regions when comparing PD patients with controls or when comparing across PD subtypes. Limitations Sample sizes in subgroups were relatively small Conclusions The role of the rostral anterior cingulate cortex for emotional processes critical in panic disorder is highlighted by this study and provides, albeit preliminary, evidence for the use of a subtype approach to advance our neurobiological insights in PD considering its involvement in the appraisal of autonomic viscero-sensory symptoms.
Databáze: OpenAIRE
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