Vitamin D Intake and Risk of Type 1 Diabetes: A Meta-Analysis of Observational Studies
| Autor: | Jiong Jack Chen, Jia-Yi Dong, Li-Qiang Qin, Shufen Han, Weiguo Zhang, Zengli Zhang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Databases Factual type 1 diabetes lcsh:TX341-641 vitamin D Subgroup analysis Review Risk Factors Internal medicine Odds Ratio medicine Vitamin D and neurology early life Humans Type 1 diabetes Pregnancy Nutrition and Dietetics business.industry Vitamins Odds ratio medicine.disease meta-analysis Observational Studies as Topic Diabetes Mellitus Type 1 Endocrinology Meta-analysis Dietary Supplements Cohort pregnancy business lcsh:Nutrition. Foods and food supply Food Science Cohort study |
| Zdroj: | Nutrients Nutrients, Vol 5, Iss 9, Pp 3551-3562 (2013) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu5093551 |
| Popis: | Vitamin D is suggested to have protective effects against type 1 diabetes. However, the results from observational studies have been inconsistent. We aimed to examine their association by conducting a meta-analysis of observational studies. Multiple databases were searched in June 2013 to identify relevant studies including both case-control and cohort studies. Either a fixed- or random-effects model was used to calculate the pooled risk estimate. We identified eight studies (two cohort studies and six case-control studies) on vitamin D intake during early life and three studies (two cohort studies and one case-control study) on maternal vitamin D intake during pregnancy. The pooled odds ratio for type 1 diabetes comparing vitamin D supplementation with non-supplementation during early life was 0.71 (95% confidence interval [CI], 0.51–0.98). Similar results were observed in the case-control subgroup analysis but not in the cohort subgroup analysis. The pooled odds ratio with maternal intake of vitamin D during pregnancy was 0.95 (95% CI, 0.66–1.36). In conclusion, vitamin D intake during early life may be associated with a reduced risk of type 1 diabetes. However, there was not enough evidence for an association between maternal intake of vitamin D and risk of type 1 diabetes in the offspring. |
| Databáze: | OpenAIRE |
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