Chitosan Hydrogel in combination with Nerolidol for healing wounds
| Autor: | Humberto Medeiros Barreto, Alessandra Braga Ribeiro, Josy Anteveli Osajima, Maria Onaira Gonçalves Ferreira, Layara Lorrana Ribeiro Leite, Edson Cavalcanti da Silva Filho, Lívio César Cunha Nunes, Idglan Sá de Lima |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Staphylococcus aureus Polymers and Plastics Nanotechnology macromolecular substances 02 engineering and technology Bacterial growth 010402 general chemistry 01 natural sciences Chitosan Mice chemistry.chemical_compound Differential scanning calorimetry Materials Chemistry Animals Antibacterial agent Nerolidol Wound Healing Organic Chemistry technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology Antimicrobial Anti-Bacterial Agents 0104 chemical sciences Thermogravimetry chemistry Self-healing hydrogels Female 0210 nano-technology Sesquiterpenes Nuclear chemistry |
| Zdroj: | Carbohydrate Polymers. 152:409-418 |
| ISSN: | 0144-8617 |
| Popis: | Chitosan is a natural polymer with antibacterial property, that is biodegradable, extremely abundant and non-toxic. This study aimed to develop and characterize chitosan hydrogels in combination with nerolidol, in order to optimize the antimicrobial and healing properties. The hydrogels were prepared using a reaction of the chitosan with acetic acid solution, followed by the addition of 2 or 4% of the nerolidol. Using thermogravimetry, differential scanning calorimetry and infrared spectroscopy, the incorporation of nerolidol in the hydrogel was confirmed. Direct contact tests using hydrogels and Staphylococcus aureus showed a synergistic effect in the materials, enabling total inhibition of bacterial growth. The hydrogel containing 2% nerolidol showed excellent healing effects. The beginning of re-epithelialization and reorganization of collagen was already observed on the 7th day of treatment. The material created proofed to be promising as a healing and antibacterial agent. |
| Databáze: | OpenAIRE |
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