Asymptomatic Strongyloidiasis among Latin American Migrants in Spain: A Community-Based Approach
| Autor: | José-Manuel Ramos-Rincón, Miriam Navarro, Corazones Sin Chagas Platform, Jara Llenas-García, María García-López, Antonio Santonja, Pedro Guevara-Hernández, Diego Torrús-Tendero, María-Paz Ventero-Martín, Concepción Gil-Anguita, Ana-Isabel Pujades-Tarraga, José-María Saugar, Violeta Ramos-Sesma, María Flores-Chávez, Philip Wikman-Jorgensen, Ana-María Garijo-Sainz, Concepción Amador-Prous, Cristina Bernal-Alcaraz |
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| Přispěvatelé: | Fundación Mundo Sano, Instituto de Investigación Sanitaria y Biomédica de Alicante (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Chagas disease medicine.medical_specialty lcsh:Medicine migrants Asymptomatic Migrants Article Serology Strongyloides stercoralis Central and South America Internal medicine medicine Immunology and Allergy Molecular Biology General Immunology and Microbiology biology business.industry lcsh:R Odds ratio medicine.disease biology.organism_classification Confidence interval Community-based intervention Infectious Diseases Strongyloidiasis Neglected tropical diseases medicine.symptom business |
| Zdroj: | Pathogens, Vol 9, Iss 511, p 511 (2020) Repisalud Instituto de Salud Carlos III (ISCIII) Pathogens Volume 9 Issue 6 |
| ISSN: | 2076-0817 |
| Popis: | Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic. Aim: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain. Methodology: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany). Results: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (< 18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases. Conclusion: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients&rsquo adherence to the medical follow-up. |
| Databáze: | OpenAIRE |
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