Quality of life after sphincter preservation surgery or abdominoperineal resection for low rectal cancer (ASPIRE): A long-term prospective, multicentre, cohort study
| Autor: | Sung-Min Lee, Doo Seok Lee, Jae Sung Kim, Heung Kwon Oh, Sunkyu Choi, Sung Il Kang, Soyeon Ahn, Keun-Wook Lee, Sung Chan Park, H.S. Lee, Kyu Joo Park, Hyun Jung Kim, Ji Won Park, Dae Kyung Sohn, Seung-Bum Ryoo, Min Hyun Kim, Bong Hwa Lee, Young Soo Park, Jae Hwan Oh, Hyoung-Chul Park, Eui Gon Youk, Duck-Woo Kim, Jung Rae Cho, Kyoung Ho Lee, Seung-Yong Jeong, Min Jung Kim, Seung Chul Heo, Rumi Shin, Young Hoon Kim, Sung-Bum Kang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Quality of life
medicine.medical_specialty Urinary function Colorectal cancer media_common.quotation_subject Sexual function Urination Internal Medicine medicine Abdominoperineal resection Rectal cancer Prospective cohort study media_common business.industry Health Policy lcsh:Public aspects of medicine Hazard ratio Public Health Environmental and Occupational Health Obstetrics and Gynecology lcsh:RA1-1270 Sphincter preservation surgery medicine.disease Surgery Psychiatry and Mental health Infectious Diseases Pediatrics Perinatology and Child Health Geriatrics and Gerontology business Cohort study Research Paper Oncological outcome |
| Zdroj: | The Lancet Regional Health: Western Pacific The Lancet Regional Health. Western Pacific, Vol 6, Iss, Pp 100087-(2021) |
| ISSN: | 2666-6065 |
| Popis: | Summary: Background: The long-term effects of radical resection on quality of life may influence the treatment selection. The objective of this study was to determine whether abdominoperineal resection has a better effect on the quality of life than sphincter preservation surgery at 3 years after surgery Methods: This prospective, cohort study included patients who underwent radical resection for low rectal cancer. The primary outcomes were European Organisation for Research and Treatment of Cancer QLQ-C30 and CR38 quality of life scores 3 years after surgery, which were compared with linear generalised estimating equations, after adjustment for baseline values, a time effect, and an interaction effect between time and treatment. The secondary outcomes included sexual-urinary functions and oncological outcomes. The study was registered with ClinicalTrials.gov (NCT01461525). Findings: Between December 2011 and August 2016, 342 patients were enrolled: 268 (78•4%) underwent sphincter preservation surgery and 74 (21•6%) underwent abdominoperineal resection. The global quality of life scores did not differ between sphincter preservation surgery and abdominoperineal resection groups (adjusted mean difference, 4•2 points on a 100-point scale; 95% confidence interval [CI], −1•3 to 9•7, p = 0•1316). Abdominoperineal resection was associated with a worse body image (9•8 points; 95% CI, 2•9 to 16•6, p = 0•0052), micturition symptoms (−8•0 points; 95% CI, -14•1 to −1•8, p = 0•0108), male sexual problems (−19•9 points; 95% CI, -33•1 to -6•7, p = 0•0032), less confidence in getting and maintaining an erection in males (0•5 points on a 5-point scale; 95% CI, 0•1 to 0•8, p = 0•0155), and worse urinary symptoms (−5•4 points on a 35-point scale; 95% CI, −8•0 to −2•7, p |
| Databáze: | OpenAIRE |
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