18F-FDG PET/CT Scans Can Identify Sub-Groups of NSCLC Patients with High Glucose Uptake in the Majority of Their Tumor Lesions
| Autor: | Geertruida H. de Bock, Mathilde Jalving, Anne M. Hendriks, Panagiotis Giannopoulos, Wim Timens, Adrienne H. Brouwers, Harry J.M. Groen, Joop D. Lefrandt |
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| Přispěvatelé: | Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Targeted Gynaecologic Oncology (TARGON) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
IMPACT type 2 diabetes mellitus CELL LUNG-CANCER medicine.medical_treatment Glucose uptake STANDARDIZED UPTAKE VALUES Standardized uptake value METABOLISM Gastroenterology 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine DOSE-ESCALATION HETEROGENEITY RECURRENCE non-small cell lung cancer medicine.diagnostic_test business.industry 18F-FDG PET/CT Cancer DIABETES-MELLITUS glycolysis medicine.disease F-18-FDG PET/CT Radiation therapy Oncology chemistry Positron emission tomography 030220 oncology & carcinogenesis 2-DEOXY-D-GLUCOSE medicine.symptom 2-Deoxy-D-glucose business RADIOTHERAPY Research Paper |
| Zdroj: | Journal of Cancer Journal of Cancer, 12(2), 562-570. IVYSPRING INT PUBL |
| ISSN: | 1837-9664 1738-6756 |
| Popis: | Background: Reprogrammed glucose metabolism is a hallmark of cancer making it an attractive therapeutic target, especially in cancers with high glucose uptake such as non-small cell lung cancer (NSCLC). Tools to select patients with high glucose uptake in the majority of tumor lesions are essential in the development of anti-cancer drugs targeting glucose metabolism. Type 2 diabetes mellitus (T2DM) patients may have tumors highly dependent on glucose uptake. Surprisingly, this has not been systematically studied. Therefore, we aimed to determine which patient and tumor characteristics, including concurrent T2DM, are related to high glucose uptake in the majority of tumor lesions in NSCLC patients as measured by 2-deoxy-2-[fluorine-18]fluoro-D-glucose (F-18-FDG) positron emission tomography (PET)/computed tomography (CT) scans.Methods: Routine primary diagnostic F-18-FDG PET/CT scans of consecutive NSCLC patients were included. Mean standardized uptake value (SUVmean) of F-18-FDG was determined for all evaluable tumor lesions and corrected for serum glucose levels according to the European Association of Nuclear Medicine Research Ltd guidelines. Patient characteristics potentially determining degree of tumor lesion glucose uptake in the majority of tumor lesions per patient were investigated.Results: The cohort consisted of 102 patients, 28 with T2DM and 74 without T2DM. The median SUVmean per patient ranged from 0.8 to 35.2 (median 4.2). T2DM patients had higher median glucose uptake in individual tumor lesions and per patient compared to non-diabetic NSCLC patients (SUVmean 4.3 vs 2.8, P = 1 mL per patient (odds ratio 0.8, 95% confidence interval 0.7-0.9).Conclusions: F-18-FDG PET/CT scans can identify sub-groups of NSCLC patients with high glucose uptake in the majority of their tumor lesions. T2DM patients had higher tumor lesion glucose uptake than non-diabetic patients. However, this was not independent of other factors such as the histological subtype and number of tumor lesions per patient. |
| Databáze: | OpenAIRE |
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