The acceptance of in silico models for REACH: Requirements, barriers, and perspectives
| Autor: | Claire Mays, Emilio Benfenati, Antonio Cassano, Simon Pardoe, Ludger Benighaus, Giuseppina Gini, Rodolfo Gonella Diaza, Ralf Knauf |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Alternative methods
0303 health sciences Chemistry(all) business.industry In silico Legislation General Chemistry 010501 environmental sciences Bioinformatics 01 natural sciences 03 medical and health sciences Chemistry Risk analysis (engineering) Commentary Medicine business QD1-999 030304 developmental biology 0105 earth and related environmental sciences Applicability domain |
| Zdroj: | Chemistry Central Journal Chemistry Central Journal, Vol 5, Iss 1, p 58 (2011) |
| Popis: | In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes. |
| Databáze: | OpenAIRE |
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