Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease—Proceedings of the first Thiopurine Task Force meeting
| Autor: | Dirk P, van Asseldonk, Jeremy, Sanderson, Nanne K H, de Boer, Miles P, Sparrow, Marc, Lémann, Azhar, Ansari, Sven H, Almer, Timothy H J, Florin, Richard B, Gearry, Chris J, Mulder, Gerassimos, Mantzaris, Ad A, van Bodegraven, Claudio, Monti |
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| Přispěvatelé: | Gastroenterology and hepatology, CCA - Innovative therapy |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Azathioprine macromolecular substances Inflammatory bowel disease Humans Medicine Adverse effect Intensive care medicine Hepatology Thiopurine methyltransferase biology business.industry Task force Gastroenterology Inflammatory Bowel Diseases medicine.disease Mercaptopurine Aminosalicylic Acids Increased risk Purines Immunology biology.protein Acute pancreatitis Drug Therapy Combination business Immunosuppressive Agents medicine.drug |
| Zdroj: | van Asseldonk, D P, Sanderson, J, de Boer, N K, Sparrow, M P, Lemann, M, Ansari, A, Almer, S H, Florin, T H J, Gearry, R B, Mulder, C J J, Mantzaris, G & van Bodegraven, A A 2011, ' Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease-Proceedings of the first Thiopurine Task Force meeting ', Digestive and Liver Disease, vol. 43, no. 4, pp. 270-276 . https://doi.org/10.1016/j.dld.2010.09.001 Digestive and Liver Disease, 43(4), 270-276. Elsevier |
| ISSN: | 1590-8658 |
| DOI: | 10.1016/j.dld.2010.09.001 |
| Popis: | Thiopurines, such as azathioprine and mercaptopurine, are of pivotal importance in the treatment of inflammatory bowel disease. Although these drugs have been used for several decades, still many questions remain unanswered.To provide an overview of clinically and scientifically challenging topics concerning thiopurine therapy in inflammatory bowel disease treatment.The first meeting of the Thiopurine Task Force Interest Group was held during the 2009 United European Gastroenterology Week in London (GASTRO2009). The topics of this meeting were of particular clinical and scientific interest. Additional literature was identified by performing a Pubmed search using the search terms 'inflammatory bowel disease', 'azathioprine', '6-mercaptopurine' and 'thioguanine'.The following topics were discussed: therapeutic drug monitoring; the synergy of thiopurines with aminosalicylates and allopurinol; serious adverse events such as opportunistic infections, hepatotoxicity, carcinogenicity and pancreatitis; prolongation of thiopurines during clinical remission; indications for thiopurines in the postoperative setting; and the potential use of thioguanine. Specific interesting and clinically relevant topics for potential future research are provided.Thiopurines remain central to inflammatory bowel disease treatment, although future studies are required to substantiate a more personalised medicine approach to their use. |
| Databáze: | OpenAIRE |
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