Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine
| Autor: | Laura Téblick, Pierre Van Damme, Severien Van Keer, Alex Vorsters, Jade Pattyn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Immunology Urine Alphapapillomavirus Urinalysis Antibodies Viral 03 medical and health sciences HPV serology Immunogenicity Vaccine 0302 clinical medicine Predictive Value of Tests First void urine humaan papillomavirus Humans Immunology and Allergy Medicine Papillomavirus Vaccines HPV antibodies HPV vaccination biology business.industry Immunogenicity Papillomavirus Infections Non invasive HPV infection Reproducibility of Results virus diseases medicine.disease Virology female genital diseases and pregnancy complications urine Vaccination Hpv testing 030104 developmental biology Perspective biology.protein Female Human medicine Antibody business lcsh:RC581-607 Biomarkers 030215 immunology |
| Zdroj: | Frontiers in Immunology, Vol 11 (2020) Frontiers in immunology Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2020.01657/full |
| Popis: | The potential of first-void (FV) urine as a non-invasive method to monitor human papillomavirus (HPV) vaccination has been reported, mainly focusing on urine as a sample to assess HPV DNA. Besides HPV DNA, vaccine-induced HPV antibodies originating from cervicovaginal secretions were recently shown to be detectable in FV urine as well. This presents a novel opportunity for non-invasive sampling to monitor HPV antibody status in women participating in large epidemiological studies and HPV vaccine trials. The simultaneous assessment of both HPV infection and immunogenicity on a non-invasive, readily obtained sample is particularly attractive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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