Improved Survival of Idiopathic Dilated Cardiomyopathy in the 1990s
| Autor: | Takashi Nakamura, Akihiro Azuma, Atsuhide Hirata, Masao Nakagawa, Toshiro Kuribayashi, Satoshi Hirasaki, Hiroshi Kunishige, Masayuki Hyogo, Tatsuya Kawasaki, Hiroki Sugihara, Takatomo Shima, Kazuto Yamamoto, Akiko Matsuo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male Inotrope medicine.medical_specialty Heart disease Physiology Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Ventricular Function Left Group B Internal medicine Idiopathic dilated cardiomyopathy medicine Humans Survival rate Aged Ejection fraction biology business.industry Dilated cardiomyopathy Angiotensin-converting enzyme Middle Aged Prognosis medicine.disease Survival Analysis Surgery Cardiology biology.protein Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Japanese Circulation Journal. 63:333-338 |
| ISSN: | 1347-4839 0047-1828 |
| DOI: | 10.1253/jcj.63.333 |
| Popis: | To analyze the recent change in the long-term survival of patients with dilated cardiomyopathy (DCM), the present study comprised consecutive 111 patients with ejection fraction50% and left ventricular end-diastolic diameter58 mm. who were admitted to hospital from January 1983 to December 1994. The patients were divided into 2 groups: group A who were diagnosed before 1989 and group B diagnosed after 1990. Basic characteristics at diagnosis, including age, NYHA functional class, left ventricular end-diastolic diameter and ejection fraction, were similar between these 2 groups. Calculated survival rate at 5 years was 90.0% in group B in contrast to 62.3% in group A. Event-free survival also improved in group B. In group B, beta-blockers and angiotensin converting enzyme inhibitors were more frequently used than in group A (p0.0001) whereas digitalis and other positive inotropic agents were significantly less used. Left ventricular ejection fraction was significantly improved during the follow-up period in patients treated with beta-blockers compared with those not treated with beta-blockers. These data indicate a significant improvement in the survival of patients with dilated cardiomyopathy after 1990, which may be explained by the change of medical treatment, especially the use of beta-blockers. |
| Databáze: | OpenAIRE |
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