The intracellular domain of Notch ligand Delta1 induces cell growth arrest
| Autor: | Thomas Maciag, Vihren Kolev, Olga Sideleva, Igor Prudovsky, Irene Graziani, Barry W. Larman, Doreen Kacer, Radianna Trifonova, Maria F. Duarte, Raffaella Soldi, Deena Small |
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| Rok vydání: | 2005 |
| Předmět: |
Notch
Biophysics Notch signaling pathway Senescence Ligands Cleavage (embryo) Biochemistry Mice Structural Biology Cyclin-dependent kinase Genetics Animals Humans Molecular Biology Cellular Senescence Cell Proliferation p21 DNA synthesis biology Cell growth Intracellular Signaling Peptides and Proteins Membrane Proteins Cell Biology Transmembrane protein Protein Structure Tertiary Cell biology Notch proteins NIH 3T3 Cells biology.protein Notch binding Delta intracellular domain Intracellular |
| Zdroj: | FEBS Letters. 579:5798-5802 |
| ISSN: | 0014-5793 |
| Popis: | Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The Delta1 ligand also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. We demonstrate that the expression of the intracellular domain of Delta1 results in a non-proliferating senescent-like cell phenotype which is dependent on the expression of the cell cycle inhibitor, p21, and is abolished by co-expression of constitutively active Notch1. These data suggest a new intracellular role for Delta1. |
| Databáze: | OpenAIRE |
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