Perinatal or early-postnatal cytomegalovirus infection in preterm infants under 34 weeks gestation born to CMV-seropositive mothers within a high-seroprevalence population
| Autor: | Marisa Márcia Mussi-Pinhata, Maria Aparecida do Carmo Rego, Aparecida Yulie Yamamoto, Patrícia Cristina Gomes Pinto, Cristina Calixto, Márcia Soares Freitas da Motta |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Human cytomegalovirus medicine.medical_specialty Opportunistic infection Population Congenital cytomegalovirus infection Cytomegalovirus Gestational Age Infant Premature Diseases Antibodies Viral Pregnancy Humans Medicine Seroprevalence Prospective Studies Pregnancy Complications Infectious education Prospective cohort study education.field_of_study business.industry Obstetrics Infant Newborn virus diseases medicine.disease Infectious Disease Transmission Vertical Cytomegalovirus Infections Pediatrics Perinatology and Child Health Immunology Gestation Female business Infant Premature |
| Zdroj: | The Journal of Pediatrics. 145:685-688 |
| ISSN: | 0022-3476 |
| Popis: | In a prospective study, we evaluated the frequency, correlates, and clinical significance of perinatal or early-postnatal cytomegalovirus (CMV) infection in34-week-gestation infants (n=95) born to CMV-seropositive mothers. None had congenital CMV infection. Overall, 21 (22.1%; 95% CI=14.2-31.8) infants were found to be infected; 10 excreted CMV at60 days, and 11 had later excretion. Blood transfusion, birth weight, and vaginal delivery were not associated factors. Receiving natural breast milk within the first 30 days (OR=4.5, P=.02) or for30 days (OR=7.9, P.01) was associated with infection. Only one (4.8%) of the infected infants was symptomatic. For34-week-gestation infants, frequency of perinatal and early-postnatal CMV infection is high. Early or prolonged exposure to breast milk is an associated factor. However, most infections are asymptomatic, indicating that CMV infection in preterm infants within such a population is a serious problem infrequently. |
| Databáze: | OpenAIRE |
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