The effects of benzodiazepines on K+-stimulated release of GABA

Autor:	P.R. Mitchell, I.L. Martin
Rok vydání:	1978
Předmět:	Male Pharmacology Cortical tissue Diazepam Time Factors Chemistry Aminobutyrates In Vitro Techniques Stimulation Chemical In vitro Rats Flurazepam Cellular and Molecular Neuroscience Anti-Anxiety Agents In vivo Potassium Animals Pentylenetetrazole gamma-Aminobutyric Acid Volume concentration
Zdroj:	Neuropharmacology. 17:317-320
ISSN:	0028-3908
Popis:	The effects of benzodiazepines on the in vitro K+ stimulated release of 3H-GABA were investigated in rat cortical tissue. A facilitation of K+ — induced release was seen at a low concentration (10−6M), which is of the same order as that found by other workers to protect against pentylenetetrazol-induced convulsions in vivo. At a much higher concentration (10−4 M) an inhibition of release was evident.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9de3fb18b099897a5a154f8b63b478 https://doi.org/10.1016/0028-3908(78)90118-1 Zobrazit plný text záznamu