Omega-3 PUFAs and gut microbiota: A preventive approach for colorectal cancer
| Autor: | Giovanni Tomasello, Marco Giammanco, Francesco Carini, Giammanco M, Margherita Mazzola |
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| Přispěvatelé: | Giammanco,M, Mazzola,M, Giammanco,MM, Tomasello,G, Carini,F |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
ω-3 PUFAs gut microbiota biology QH301-705.5 Colorectal cancer business.industry Biochemistry (medical) colorectal cancer Plant Science Gut flora biology.organism_classification medicine.disease Bioinformatics digestive system General Biochemistry Genetics and Molecular Biology Mucosal Associated Lymphatic Tissue (MALT) prevention chemistry medicine Biology (General) business colorectale cancer prevention gut microbiota mucosal associated lymphatic tissue omega-3 PUFAs Polyunsaturated fatty acid |
| Zdroj: | Journal of Biological Research (2021) |
| ISSN: | 2284-0230 1826-8838 |
| DOI: | 10.4081/jbr.2021.9954 |
| Popis: | The influence of diet on the composition of the intestinal microbiota and related pathologies has been known for some time. Some classes of nutrients, such as fatty acids belonging to the omega 3 series, have particular effects on the bacteria that make up the intestinal microbiota. ω-3 PUFAs affect the gut microbiota in three different ways: by modulating the type and abundance of intestinal bacteria, by regulate SCFAs levels, and by alter the levels of proinflammatory mediators. Through these modalities, ω-3 PUFAs could be useful for the prevention of intestinal diseases such as Colorectal Cancer (CRC). The ability of ω-3 PUFAs to modulate the intestinal inflammatory response, to preserve the integrity of the intestinal mucosa and to modulate the bacterial composition of the intestine, could be useful as a preventive strategic approach to hinder the development of CRC. |
| Databáze: | OpenAIRE |
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