Evaluation of Simulated Lesions as Surrogates to Clinical Lesions for Thoracic CT Volumetry: The Results of an International Challenge
| Autor: | Jayashree Kalpathy-Cramer, Aria Pezeshk, Rudresh Jarecha, Nicholas Petrick, Maria Athelogou, Marthony Robins, Andrew J. Buckler, Berkman Sahiner, Nancy A. Obuchowski, Ehsan Samei |
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| Rok vydání: | 2019 |
| Předmět: |
Lung Neoplasms
Quantitative imaging Databases Factual Article Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Humans Thoracic ct Medicine Radiology Nuclear Medicine and imaging Segmentation Lung Equivalence (measure theory) Reproducibility Phantoms Imaging business.industry Reproducibility of Results Repeatability Cone-Beam Computed Tomography Confidence interval 030220 oncology & carcinogenesis business Nuclear medicine Algorithms |
| Zdroj: | Acad Radiol |
| ISSN: | 1076-6332 |
| Popis: | RATIONALE AND OBJECTIVES To evaluate a new approach to establish compliance of segmentation tools with the computed tomography volumetry profile of the Quantitative Imaging Biomarker Alliance (QIBA); and determine the statistical exchangeability between real and simulated lesions through an international challenge. MATERIALS AND METHODS The study used an anthropomorphic phantom with 16 embedded physical lesions and 30 patient cases from the Reference Image Database to Evaluate Therapy Response with pathologically confirmed malignancies. Hybrid datasets were generated by virtually inserting simulated lesions corresponding to physical lesions into the phantom datasets using one projection-domain-based method (Method 1), two image-domain insertion methods (Methods 2 and 3), and simulated lesions corresponding to real lesions into the Reference Image Database to Evaluate Therapy Response dataset (using Method 2). The volumes of the real and simulated lesions were compared based on bias (measured mean volume differences between physical and virtually inserted lesions in phantoms as quantified by segmentation algorithms), repeatability, reproducibility, equivalence (phantom phase), and overall QIBA compliance (phantom and clinical phase). RESULTS For phantom phase, three of eight groups were fully QIBA compliant, and one was marginally compliant. For compliant groups, the estimated biases were -1.8 ± 1.4%, -2.5 ± 1.1%, -3 ± 1%, -1.8 ± 1.5% (±95% confidence interval). No virtual insertion method showed statistical equivalence to physical insertion in bias equivalence testing using Schuirmann's two one-sided test (±5% equivalence margin). Differences in repeatability and reproducibility across physical and simulated lesions were largely comparable (0.1%-16% and 7%-18% differences, respectively). For clinical phase, 7 of 16 groups were QIBA compliant. CONCLUSION Hybrid datasets yielded conclusions similar to real computed tomography datasets where phantom QIBA compliant was also compliant for hybrid datasets. Some groups deemed compliant for simulated methods, not for physical lesion measurements. The magnitude of this difference was small ( |
| Databáze: | OpenAIRE |
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