A new significant and independent risk factor for falls in elderly men and women: a low creatinine clearance of less than 65 ml/min
| Autor: | Ze’ev Mazor, Hannes B. Stähelin, Erich Schacht, Laurent Dukas |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Urology Renal function Poison control Kidney Cohort Studies chemistry.chemical_compound Calcitriol Medicine Humans Risk factor education Aged Probability Creatinine education.field_of_study business.industry Hydroxycholecalciferols Incidence (epidemiology) Kidney metabolism Surgery chemistry Accidental Falls Female business Cohort study |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 16(3) |
| ISSN: | 0937-941X |
| Popis: | Objectives: Because impaired renal function is detrimental for the conversion of calcidiol to calcitriol (D-hormone) and since D-hormone analogues have been shown to decrease the risk of falls, we investigated whether creatinine clearance (CrCl) is associated with the number of fallers and falls in elderly men and women. Methods: Within a randomized controlled study, we observed for 36 weeks 186 placebo-treated community-dwelling elderly men and women over 70, in an attempt to determine the influence of baseline CrCl on calcitropic hormone serum levels, as well as the influence of baseline CrCl on the number of fallers and falls over time. With the help of questionnaires, we regularly assessed fall incidence and frequency. The risk of falls and the risk of becoming a faller were assessed in multivariate-controlled logistic regression models according to a cutoff value of the CrCl set at 65 ml/min. Results: At baseline, serum levels of 1.25(OH)2D3 and iPTH were, in multivariate-controlled analyses, significantly associated with CrCl (p |
| Databáze: | OpenAIRE |
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