Antibiotic use in ambulatory care in Europe (ESAC data 1997–2002): trends, regional differences and seasonal fluctuations

Autor: Elseviers, MONIQUE M., Ferech, Matus, VANDER STICHELE, ROBERT H., Goossens, Herman, Mittermayer, Helmut, Metz, Sigrid, Markova, Boyka, Andrasevic, Arjana, Francetic, Igor, Bagatzouni, Despo, Vlcek, Jiri, Monnet, DOMINIQUE L., ANKER NIELSEN, Annemette, Rootslane, Ly, Huovinen, Pentti, Paakkari, Pirkko, Cavalié, Philippe, Guillemot, Didier, Kern, Winfried, Schroeder, Helmut, Giamarellou, Helen, Antoniadou, Anastasia, Ternak, Gabor, Kristinsson, Karl, Cunney, Robert, Oza, Ajay, Raz, Raul, Cornaglia, Giuseppe, Berzina, Sandra, Valenteliene, Rolanda, Hemmer, Robert, Bruch, Marcel, Borg, Michael, Zarb, Peter, Janknegt, Robert, Filius, Margreet, SALVESEN BLIX, Hege, Hryniewicz, Waleria, Grzesiowski, Pawel, Caldeira, Luis, Codita, Irina, Stratchounski, Leonid, Ratchina, Svetlana, Foltan, Viliam, Tesar, Tomas, Cizman, Milan, Campos, Jose', Cars, Otto, Skoog, Gunilla, Mölstad, Sigvard, Masiero, Giuliano, Unal, Serhat, Davey, Peter
Přispěvatelé: ESAC project group
Rok vydání: 2006
Předmět:
Quinolone antibacterial agents
antibiotic consumption
Pediatrics
medicine.medical_specialty
Time Factors
Streptogramins
Epidemiology
Drug Utilization Review
Antibiotic resistance
ambulatory care
Ambulatory care
Antibiotics
Anatomical therapeutic chemical
sulfonamides
Environmental health
medicine
Humans
Pharmacology (medical)
Practice Patterns
Physicians'
Antibiotic use
Settore SECS-P/01 - Economia Politica
Retrospective Studies
Consumption (economics)
Sulfonamides
seasonality
ATC/DDD classification
penicillins
cephalosporins
quinolones
macrolides
tetracyclines
business.industry
Pharmacoepidemiology
Ambulatory medical care -- Case studies
Penicillium
Seasonality
medicine.disease
Drug Utilization
Macrolide antibiotics
Anti-Bacterial Agents
Cephalosporins
Europe
Defined daily dose
Tetracyclines
Seasons
business
Regional differences
Zdroj: Pharmacoepidemiology and drug safety
ISSN: 1099-1557
1053-8569
Popis: Purpose: The ESAC project (European Study on Antibiotic Consumption) aims to collect antibiotic-use data through a European network of national surveillance systems. This paper reports on the retrospective data collection in ambulatory care for the period 1997–2002. Methods: Valid data of antibiotic consumption of 24 European countries for 2002 and of 18 countries for the entire 6-year period was classified according to the Anatomical Therapeutic Chemical Classification (ATC) and expressed in defined daily dose (DDD) per 1000 inhabitants per day (DID). Overall and subgroup comparison of antibiotic consumption over time as well as between geographical clusters was performed. Results: Total use of antibiotics in Europe remained at a median level of 20 DID in the period 1997–2002 with a wide variation between countries ranging from 9.8 DID in The Netherlands to 32.2 DID in France. A substantial increase in subclass consumption of co-amoxiclav and fluoroquinolones was noted while the use of narrow-spectrum penicillins, erythromycin, quinolones and sulfonamides decreased. Total consumption as well as seasonal fluctuations showed remarkable geographical clustering with low consumption and low variation between summer and winter in the North, high consumption patterns in the South and a mixed model in the East. Conclusions: Within the ESAC project, valid time series of antibiotic-use data are publicly available now, enabling to improve the study of determinants of use, the evaluation of governmental antibiotic consumption policies and the investigation of the associated emergence of antibiotic resistance.
peer-reviewed
Databáze: OpenAIRE
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