| Autor: |
Jin Hu, Qiang Chen, Hongrui Zhu, Lichao Hou, Wei Liu, Qihua Yang, Huidan Shen, Guolin Chai, Boxin Zhang, Shaoxuan Chen, Zhiyu Cai, Chongxin Wu, Fan Hong, Hongda Li, Sifang Chen, Naian Xiao, Zhan-xiang Wang, Xueqin Zhang, Bo Wang, Liang Zhang, Wei Mo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Neuron. |
| ISSN: |
1097-4199 |
| Popis: |
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ) plaques, whose impact on the mechanical properties of the surrounding brain tissues is unclear. Microglia sense and integrate biochemical cues of the microenvironment. However, whether the microglial mechanosensing pathways influence AD pathogenesis is unknown. Here, we surveyed the elevated stiffness of Aβ-plaque-associated tissues and observed the selective upregulation of the mechanosensitive ion channel Piezo1 in Aβ-plaque-associated microglia. Piezo1 sensed the stiffness stimuli of Aβ fibrils and subsequently induced Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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