Bevacizumab-containing regimen in relapsed/progressed brain tumors: a single-institution experience
| Autor: | Claudio Di Biasi, Giulia Varrasso, Carlo Dominici, Paola Papoff, Eva Ferrara, Amalia Schiavetti, Maria Giovanna Mollace |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Bevacizumab bevacizumab Young Adult 03 medical and health sciences 0302 clinical medicine children Refractory Glioma Internal medicine Antineoplastic Combined Chemotherapy Protocols Temozolomide Humans Medicine Cerebellar Neoplasms Child irinotecan Salvage Therapy relapse Medulloblastoma Brain Neoplasms business.industry General Medicine medicine.disease brain tumors Confidence interval Irinotecan Regimen Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Female Neurology (clinical) Neoplasm Recurrence Local business 030217 neurology & neurosurgery Progressive disease medicine.drug |
| Zdroj: | Child's Nervous System. 35:1007-1012 |
| ISSN: | 1433-0350 0256-7040 |
| DOI: | 10.1007/s00381-019-04117-z |
| Popis: | The aim of the study is to assess tumor response, treatment-related toxicities, progression-free survival (PFS), and overall survival (OS) in patients with relapsed/refractory brain tumors treated with bevacizumab-containing regimen. Patients that had received I and II line treatments with or without megatherapy were included. Doses and schedule were as follows: bevacizumab (BVZ) 10 mg/kg i.v. with irinotecan (IRI) 150 mg/m2 i.v. every 2 weeks ± temozolamide (TMZ) 200 mg/m2 p.o. daily for 5 days every 4 weeks. TMZ was omitted in heavily pretreated cases. Between 2013 and 2018, 12 patients (3F/9M), median age 161 months (range 66–348), affected with medulloblastoma (n 7), or low-grade glioma (n 2), or high-grade glioma (n 3), received BVZ/IRI association (median courses 20, range 4–67); 3 of them continued single-agent BVZ (median courses 23, range 8–39). TMZ (median courses 8, range 2–26) was administered in eight patients and then stopped in three of them because of myelotoxicity or lack of compliance. Treatment was well tolerated. After 3 months, two complete responses, two partial responses, seven stable diseases, and one progressive disease were observed. Nine cases experienced an improvement in neurological symptoms. Median time to progression was 11 months (95% confidence interval, 4–18 months). Six-month and 2-year PFS were 75% and 42%, respectively. The OS is 33%; interestingly, two cases (one medulloblastoma and one high-grade glioma) are progression-free off-therapy since 30 and 48 months, respectively. BVZ/IRI association ± TMZ showed encouraging therapeutic activity and low toxicity in this series of relapsed/refractory brain tumors. |
| Databáze: | OpenAIRE |
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