Vascular responses of human skin to injection of substance P and mechanism of action
| Autor: | Angela Coutts, Joseph L. Jorizzo, Robin A.J. Eady, Malcolm W. Greaves |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Erythema Xanthones Indomethacin Human skin Substance P Tachyphylaxis Pharmacology chemistry.chemical_compound Heart Rate Internal medicine medicine Humans Mast Cells Cimetidine Skin Diphenhydramine Endocrinology chemistry Mechanism of action Regional Blood Flow Thioxanthenes Prostaglandins medicine.symptom Histamine medicine.drug |
| Zdroj: | European journal of pharmacology. 87(1) |
| ISSN: | 0014-2999 |
| Popis: | The mechanism of cutaneous inflammation caused by substance P in human skin was assessed in five subjects receiving i.d. injections (5–405 pmol) at pH 7.2 as compared to histamine (0.08–1.6 nmol), compound 48/80 (100 ng) and solvent control. Both substance P and histamine produced sigmoid dose-response curves for the following parameters: 1 min and 5 min planimetrically measured areas of erythema, and mean diameter of weal. Substance P pretreatment induced tachyphylaxis, as assessed by standard methods with adequate controls, to both histamine and to substance P and vice versa. Erythema following substance P i.d. was not blocked by a constricting band. Diphenhydramine, and to a lesser extent doxantrazole, (but not cimetidine or indomethacin) when assessed as inhibitors after oral pretreatment, did shift dose response curves for histamine and substance P to the right. Light and electron microscopic assessment of mast cells was compared in substance P and solvent control injected human skin. These results support a possible role for substance P in cutaneous inflammation acting either directly or via histamine release from mast cells. |
| Databáze: | OpenAIRE |
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