A Study of Therapy for Pediatric Hepatoblastoma: Prevention and Treatment of Pulmonary Metastasis
| Autor: | Yagi M, Masanori Uchiyama, Makoto Iwafuchi, Kanada S, M. Naito, K Tsukada, Yasushi Iinuma |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Hepatoblastoma
Male medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Gastroenterology Metastasis Pneumonectomy Unresected Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Survival rate Patient Care Team Chemotherapy Lung business.industry Liver Neoplasms Respiratory disease Infant medicine.disease Combined Modality Therapy digestive system diseases Surgery Survival Rate medicine.anatomical_structure Chemotherapy Adjuvant Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | European Journal of Pediatric Surgery. 9:142-145 |
| ISSN: | 1439-359X 0939-7248 |
| DOI: | 10.1055/s-2008-1072230 |
| Popis: | Our results of treatment for pediatric hepatoblastoma are presented with special emphasis on pulmonary metastasis. The pulmonary metastasis rate of hepatoblastoma was 44% (11/25). In 19 patients with resected hepatoblastomas, the 5-year survival rate without pulmonary metastasis was 90% (9/10); while with pulmonary metastasis it was 22% (2/9). Six patients with unresected hepatoblastomas all died within 4 months regardless of chemotherapy and/or metastasis. To improve survival in patients with hepatoblastoma, preoperative or postoperative chemotherapy was thought to be essential for tumors extending over 2 hepatic segments and having predictable factors for pulmonary metastasis (large size or histological evidence of capsular invasion). A long-term multidisciplinary approach including hepatic lobectomy, current multiagent chemotherapy (including CDDP, THP-ADR), and partial pulmonary resection for localized lung areas with metastases would ultimately be needed. |
| Databáze: | OpenAIRE |
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