Are we Justified Doing Routine Intracytoplasmic Sperm Injection in Nonmale Factor Infertility? A Retrospective Study Comparing Reproductive Outcomes between In vitro Fertilization and Intracytoplasmic Sperm Injection in Nonmale Factor Infertility
| Autor: | Rubina Pandit, Reeta Biliangady, Poornima Kinila, Uma Maheswari Sundhararaj, Ambika G Swamy, Nutan Kumari Tudu, Indu S. T. Gopal |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty medicine.medical_treatment Insemination lcsh:Gynecology and obstetrics ICSI Intracytoplasmic sperm injection 03 medical and health sciences 0302 clinical medicine Human fertilization medicine lcsh:RG1-991 reproductive and urinary physiology Gynecology 030219 obstetrics & reproductive medicine In vitro fertilisation Assisted reproductive technology business.industry urogenital system medicine.disease Sperm nonmale factor infertility 030104 developmental biology Reproductive Medicine IVF embryonic structures Original Article Live birth business therapeutics |
| Zdroj: | Journal of Human Reproductive Sciences Journal of Human Reproductive Sciences, Vol 12, Iss 3, Pp 210-215 (2019) |
| ISSN: | 1998-4766 0974-1208 |
| Popis: | Introduction: Intracytoplasmic sperm insemination (ICSI) came into use in 1992 to improve fertilization in couples with male factor infertility undergoing in vitro fertilization (IVF) or in couples with fertilization failure in a prior IVF cycle. Our aim was to find out if routine ICSI has any additional benefit over conventional IVF in non male factor cases in modern Assisted Reproductive Technology (ART). Methods: This is a retrospective single centre study undertaken at a private IVF center. A total of 350 patients with normal male factor were included in the study of which 186 underwent conventional IVF and 134 were subjected to ICSI. They were then compared for various reproductive parameters with Live Birth Rate (LBR) being the primary outcome. P value < 0.05 was considered statistically significant. Results: Fertilization rates (89.99% vs 85.1%), Blastocyst formation rates (62.86% vs 50.61%) and clinical pregnancy rates (37.85% vs 32.35%) were found to be higher in the IVF group compared to the ICSI group though not statistically significant. The live birth rates in the IVF group was also higher than the ICSI group (32.71% vs 24.26%). Conclusion: IVF edged over ICSI in all aspects resulting in better clinical outcome with higher take home babies in non-male factor infertility. Our results show that routine ICSI should not be used as a blanket therapy for all cases in ART. |
| Databáze: | OpenAIRE |
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