Cell cholesterol efflux: integration of old and new observations provides new insights
| Autor: | David L. Williams, Michael C. Phillips, Ginny Kellner-Weibel, George H. Rothblat, V. Atger, Margarita de la Llera-Moya |
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| Rok vydání: | 1999 |
| Předmět: |
Cell type
Phospholipid efflux Cell Phospholipid QD415-436 Biology Biochemistry chemistry.chemical_compound Endocrinology influx medicine Extracellular Cholesterol cholesterol Cell Biology efflux Cell biology tissue culture cells lipoproteins medicine.anatomical_structure chemistry high density lipoprotein lipids (amino acids peptides and proteins) Efflux Flux (metabolism) |
| Zdroj: | Journal of Lipid Research, Vol 40, Iss 5, Pp 781-796 (1999) |
| ISSN: | 0022-2275 |
| DOI: | 10.1016/s0022-2275(20)32113-1 |
| Popis: | Numerous studies using a variety of cell/accep- tor combinations have demonstrated differences in cho- lesterol efflux among cells. These studies also show that dif- ferent acceptors, ranging from simple molecules like cyclodextrins to serum, stimulate efflux through a variety of mechanisms. By combining early observations with data de- rived from recent studies, it is now possible to formulate a model for cell cholesterol efflux which proposes that an ar- ray of different mechanisms, including aqueous diffusion, lipid-free apolipoprotein membrane microsolubilization, and SR-BI-mediated cholesterol exchange contribute to cholesterol flux. In this model the relative importance of each mechanism would be determined both by the cell type and the nature of the extracellular cholesterol acceptor. — Rothblat, G. H., M. de la Llera-Moya, V. Atger, G. Kellner- Weibel, D. L. Williams, and M. C. Phillips. Cell cholesterol efflux: integration of old and new observations provides new insights. J. Lipid Res. 1999. 40: 781-796. |
| Databáze: | OpenAIRE |
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