Association of Bethesda category and molecular mutation in patients undergoing thyroidectomy
| Autor: | Galit Avior, Veronique-Isabelle Forest, Magdalena Peeva, Richard J. Payne, Michael P. Hier, Michael Tamilia, Marc Pusztaszeri, Marco A. Mascarella, Alex Mlynarek |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Thyroid nodules Adult Male medicine.medical_specialty medicine.medical_treatment EIF1AX Biopsy Fine-Needle Disease Internal medicine Medicine Humans Thyroid Neoplasms Thyroid Nodule Thyroid cancer Aged Retrospective Studies business.industry Gene Expression Profiling Thyroid Thyroidectomy Nodule (medicine) Retrospective cohort study Middle Aged medicine.disease medicine.anatomical_structure Otorhinolaryngology Mutation Female medicine.symptom business |
| Zdroj: | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-LaryngologyCervico-Facial SurgeryREFERENCES. 47(1) |
| ISSN: | 1749-4486 |
| Popis: | OBJECTIVES The aim of this study was to ascertain the relationship between Bethesda category and molecular mutation of thyroid nodules in patients undergoing thyroidectomy. DESIGN A retrospective cohort of patients who underwent thyroidectomy following needle biopsy and molecular profile testing was performed. SETTING Two tertiary care academic hospitals. PARTICIPANTS Consecutive patients with a dominant thyroid nodule who underwent both USFNA and molecular profile testing followed by thyroidectomy were included in the study. MAIN OUTCOME AND MEASURES The main outcome was postoperative diagnosis of thyroid cancer and aggressivity of disease based on histopathological variants, nodal metastasis or extra-thyroidal extension. Associations between Bethesda category, molecular mutation and postoperative pathology was assessed using descriptive analysis and chi-square testing. RESULTS Four hundred fifty-one patients were included. 95.9% (93/97) of patients with a BRAFV600E mutation had a Bethesda category V or VI (p |
| Databáze: | OpenAIRE |
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