Factors influencing participation rates in clinical late‐effect studies of childhood cancer survivors
| Autor: | Anne Sophie Lind Helligsoe, Henrik Hasle, Christian Dehlendorff, Jeanette Falck Winther, Line Kenborg, Louise Tram Henriksen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Future studies
Childhood cancer Physical examination Affect (psychology) Central Nervous System Neoplasms 03 medical and health sciences 0302 clinical medicine Cancer Survivors Neoplasms medicine Humans Survivors Child medicine.diagnostic_test business.industry Cancer type Late effect External validation Hematology Oncology Hematologic Neoplasms 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Disease Progression Population study medicine.symptom business Follow-Up Studies 030215 immunology Demography |
| Zdroj: | Helligsø, A S L, Henriksen, L T, Kenborg, L, Dehlendorff, C, Winther, J F & Hasle, H 2021, ' Factors influencing participation rates in clinical late-effect studies of childhood cancer survivors ', Pediatric Blood & Cancer, vol. 68, no. 9, e29098 . https://doi.org/10.1002/pbc.29098 |
| DOI: | 10.1002/pbc.29098 |
| Popis: | To ensure external validation of a study population in clinical late-effect studies of childhood cancer, the participation rate must be high. This study investigated demographic data in Nordic late-effect studies and potential factors impacting participation rates such as cancer type, time since diagnosis, and duration of clinical examinations. We found 80 published studies originating from 16 cohorts, with median follow-up of 6.0 years (range 3-14). The overall participation rates ranged from 27% to 100%. The highest participation rates were seen in studies of survivors with solid tumors (92%) and the lowest in hematologic malignancies (67%) and central nervous system tumors (73%). The clinical examination in 10 studies (62.5%) lasted for more than 3 hours. Neither duration of the clinical examination nor time since diagnosis seemed to affect the participation rate. We encourage future studies to describe the recruitment process more thoroughly to improve understanding of the factors influencing participation rates. |
| Databáze: | OpenAIRE |
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