The Development of Colorado Tick Fever Virus Within Cells of the Haemopoietic System

Autor:	D. V. Dondero, E. H. Lennette, L. S. Oshiro, R. W. Emmons
Rok vydání:	1978
Předmět:	Erythrocytes Reticulocytes Erythroblasts viruses Mitosis Colorado tick fever Biology Reoviridae medicine.disease Colorado tick fever virus Virology Inclusion Bodies Viral Mice Viral replication In utero Infected cell Liver tissue medicine Animals Erythropoiesis Electron microscopic
Zdroj:	Journal of General Virology. 39:73-79
ISSN:	1465-2099 0022-1317
DOI:	10.1099/0022-1317-39-1-73
Popis:	Summary Electron microscopic examination of haemopoietic liver tissue from mice infected in utero or when newborn showed inclusions of Colorado tick fever virus within erythroblasts, reticulocytes and erythrocytes. Inclusions were also seen within erythroblastoid cells undergoing mitosis. Other evidence of virus replication within erythropoietic cells was the presence of intracytoplasmic and intranuclear fibres, which have been shown to be associated with Colorado tick fever virus replication. The findings reported here support the hypothesis that virus replication within infected erythropoietic cells occurs concurrently with differentiation of the infected cell, resulting in the presence of virions within erythrocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd954c958150e6aa8d44c05a89f431ee https://doi.org/10.1099/0022-1317-39-1-73 Zobrazit plný text záznamu