Effects of formoterol in apparently poorly reversible chronic obstructive pulmonary disease
| Autor: | Vincent A.M. Duurkens, C. J. J. Westermann, B. L. P. Maesen, J. M. M. Van Den Bosch |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Time Factors medicine.drug_class Pulmonary function testing Work of breathing Airway resistance Double-Blind Method Bronchodilator Forced Expiratory Volume Formoterol Fumarate Administration Inhalation medicine Humans Lung Diseases Obstructive Aged Cross-Over Studies Inhalation business.industry Respiratory disease Smoking respiratory system Adrenergic beta-Agonists Middle Aged medicine.disease respiratory tract diseases Ethanolamines Spirometry Anesthesia Female Formoterol business medicine.drug |
| Zdroj: | The European respiratory journal. 13(5) |
| ISSN: | 0903-1936 |
| Popis: | This randomized, double-blind, placebo-controlled, crossover study was designed to investigate the effects of the long-acting beta2-adrenoreceptor agonist formoterol fumarate in 12 current or exsmokers having chronic obstructive pulmonary disease, with a mean forced expiratory volume in one second (FEV1) 47% of predicted, poorly reversible (5.1% pred) after terbutaline sulphate inhalation. After inhaling a single dose of formoterol (6 or 24 microg), or placebo via Turbuhaler, FEV1 and pulmonary function parameters measured during quiet breathing (work of breathing (WoB) and airway resistance (Raw)) were recorded over 12 h on three test days. Immediate changes in FEV1 were modest, although each dose of formoterol caused a response >12% pred within 10 min in one subject. Compared to placebo, both doses of formoterol induced a clinically and statistically relevant improvement in WoB (>25%) and Raw (>20%), which occurred within 10 min and lasted over a period of 12 h (p < or = 0.02, analysis of variance). Thus, inhaled formoterol causes long-lasting lung functional improvements in apparently poorly reversible chronic obstructive pulmonary disease. Additional lung function measurements during quiet breathing after forced expiration tests may be useful in such patients to assess beneficial effects of bronchodilators. |
| Databáze: | OpenAIRE |
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