The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats
| Autor: | Alicja Kruszewska, Romuald Langwiński |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Serotonin Metergoline medicine.medical_specialty (+)-Naloxone Toxicology Serotonergic Synaptic Transmission 5-Hydroxytryptophan chemistry.chemical_compound Internal medicine medicine Fenclonine Animals Humans Pharmacology (medical) Pharmacology Morphine Tryptophan Antagonist Brain Rats Inbred Strains Rats Substance Withdrawal Syndrome Psychiatry and Mental health Endocrinology chemistry medicine.drug |
| Zdroj: | Drug and Alcohol Dependence. 12:273-278 |
| ISSN: | 0376-8716 |
| Popis: | It was found that 200 mg/kg of DL-p-chlorophenylalanine (PCPA) and 2 mg/kg of methergoline drugs inhibiting central serotoninergic transmission-decreased naloxone precipitated abstinence wet dog shakes in morphine-dependent rats. The inhibitory effect of PCPA was reversed by 200 mg/kg of 5-hydroxy-L-tryptophan (5-HTP) but not by the same amount of L-tryptophan (TP). 5-HTP alone (200 mg/kg) increased wet dog shakes epissodes, whereas TP alone in the same dosage practically did not have any influence on the wet dog shakes in morphine-dependent rats. These findings suggest that brain serotonin may play some role in the expression of wet dog shakes in morphine-dependent rats. |
| Databáze: | OpenAIRE |
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