ZNF668: a new diagnostic predictor of kidney renal clear cell carcinoma
| Autor: | Chuang Wei, Yijun Gao, Xiatian Chen, Peifeng Li, Cheng Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Cancer Research T cell Lymphocytes Tumor-Infiltrating Biomarkers Tumor medicine Humans Pharmacology (medical) Carcinoma Renal Cell Pathological Survival analysis Aged Neoplasm Staging Pharmacology Univariate analysis Kidney business.industry Tumor Suppressor Proteins Estrogens Complement System Proteins Dendritic Cells Dendritic cell Middle Aged Prognosis medicine.disease Survival Analysis Kidney Neoplasms Complement system medicine.anatomical_structure ROC Curve Oncology Cancer research Female business Infiltration (medical) Signal Transduction |
| Zdroj: | Anti-Cancer Drugs. 33:e491-e499 |
| ISSN: | 0959-4973 |
| Popis: | The most common pathological subtype of renal carcinoma is RCC, and its development is closely related to immune infiltration. In our study, we investigated the relationship between zinc finger protein 668 and the prognostic risk, clinical characteristics, overall survival and related pathways. We analyzed the association between ZNF668 and immune cell infiltration through the TIMER database. The results showed that the expression of ZNF668 in RCC was higher than that in normal tissues (P < 0.001). The high expression of ZNF668 is clinically relevant, such as tumor stage (P = 0.001) and TNM classification (T: P = 7.37 e-04; N: P = 0.008; M: P < 0.001). Survival analysis showed that patients with high ZNF668 expression had a significantly poor prognosis (P = 0.023). Univariate analysis showed a significant decrease in overall survival in RCC patients with high ZNF668 expression (P = 0.023). Immuno-cell infiltration showed a significant decrease in CD4+ T cell and dendritic cell infiltration in RCC patients with high expression of ZNF668. GO/KEGG analysis showed that multiple pathways were differentially enriched in the high expression pathway of ZNF668, such as complement activation, and estrogen signaling pathway. In conclusion, high ZNF668 expression is a predictor in RCC. |
| Databáze: | OpenAIRE |
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