A PstI restriction fragment length polymorphism in the 5′ untranslated region of DRD4 is not associated with schizophrenia
| Autor: | A. Petronis, Jeffrey A. Lieberman, J.L. Kennedy, H. H.M. Van Tol, D. J. Ying, O. Schoots, Andrew D. Paterson |
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| Rok vydání: | 1996 |
| Předmět: |
Five prime untranslated region
Gene Expression Regulatory Sequences Nucleic Acid PstI Dopamine mental disorders Genetics medicine Humans Deoxyribonucleases Type II Site-Specific Receptor Gene Allele frequency Biological Psychiatry Genetics (clinical) Genetic association biology Receptors Dopamine D2 Receptors Dopamine D4 Psychiatry and Mental health Protein Biosynthesis Schizophrenia biology.protein bacteria Restriction fragment length polymorphism Polymorphism Restriction Fragment Length medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0955-8829 |
| DOI: | 10.1097/00041444-199624000-00004 |
| Popis: | We detected a PstI restriction fragment length polymorphism in the 5'-non-coding region of the dopamine D4 receptor gene (DRD4), making it the seventh known polymorphism for DRD4. DNA polymorphisms in the putative regulatory region of DRD4 are of interest because of the reported six-fold increase in D4 receptors in post-mortem schizophrenic brain tissue [Seeman P, Guan HC, Van Tol HHM (1993) Nature, 365, 441-445]. We found no difference in the PstI allele frequencies between DSM-III-R schizophrenia patients (0.76 and 0.24, n = 41), and matched control Caucasians (0.77 and 0.23, n = 46). The PstI DRD4 polymorphism has potential use in linkage and association studies with neuropsychiatric and cardiovascular disorders. |
| Databáze: | OpenAIRE |
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