Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses
| Autor: | Vanessa Delfosse, William Bourguet, Patrick Balaguer, Marina Grimaldi |
|---|---|
| Přispěvatelé: | Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Receptors Cytoplasmic and Nuclear Estrogen receptor [SDV.CAN]Life Sciences [q-bio]/Cancer Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Nuclear receptors Internal medicine medicine Animals Humans Endocrine system Receptor MESH: Endocrine Disruptors/toxicity Receptors Cytoplasmic and Nuclear/metabolism Endocrine disruptors Low doses Pregnane X receptor General Immunology and Microbiology Low dose Cooperative binding Mycoestrogen General Medicine 3. Good health 030104 developmental biology Endocrinology Nuclear receptor Biochemistry chemistry General Agricultural and Biological Sciences |
| Zdroj: | Comptes Rendus Biologies Comptes Rendus Biologies, Elsevier, 2017, 340 (9-10), pp.414-420. ⟨10.1016/j.crvi.2017.08.002⟩ |
| DOI: | 10.1016/j.crvi.2017.08.002⟩ |
| Popis: | International audience; Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous substances that cause adverse effects in the endocrine system mainly by interacting with nuclear hormone receptors (NRs). Humans are generally exposed to low doses of pollutants, and current researches aim at deciphering the mechanisms accounting for the health impact of EDCs at environmental concentrations. Our correlative analysis of structural, interaction and cell-based data has revealed a variety of, sometimes unexpected, binding modes, reflecting a wide range of EDC affinities and specificities. Here, we present a few representative examples to illustrate various means by which EDCs achieve high-affinity binding to NRs. These examples include the binding of the mycoestrogen α-zearalanol to estrogen receptors, the covalent interaction of organotins with the retinoid X- and peroxisome proliferator-activated receptors, and the cooperative binding of two chemicals to the pregnane X receptor. We also discuss some hypotheses that could further explain low-concentration effects of EDCs with weaker affinity towards NRs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|