Antibiotic-loaded bone void filler accelerates healing in a femoral condylar rat model
| Autor: | R. R. Cobb, J. F. Kirk, K. M. Bedigrew, A. Kimbler, I. Finger Baker, Joseph C. Wenke, G. Ritter, Stefanie M. Shiels |
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| Rok vydání: | 2016 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Antibiotics Dentistry Microbial Sensitivity Tests Bone healing law.invention Rats Nude 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine law Tobramycin medicine Animals Orthopedics and Sports Medicine Femur Fracture Healing 030222 orthopedics Bone Demineralization Technique Bone Transplantation business.industry Drug Administration Routes Osteomyelitis dBm Staphylococcal Infections medicine.disease Anti-Bacterial Agents Bioactive glass Surgery business Femoral Fractures 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Bone & Joint Journal. :1126-1131 |
| ISSN: | 2049-4408 2049-4394 |
| DOI: | 10.1302/0301-620x.98b8.37634 |
| Popis: | AimsDemineralised bone matrix (DBM) is rarely used for the local delivery of prophylactic antibiotics. Our aim, in this study, was to show that a graft with a bioactive glass and DBM combination, which is currently available for clinical use, can be loaded with tobramycin and release levels of antibiotic greater than the minimum inhibitory concentration for Staphylococcus aureus without interfering with the bone healing properties of the graft, thus protecting the graft and surrounding tissues from infection.Materials and MethodsAntibiotic was loaded into a graft and subsequently evaluated for drug elution kinetics and the inhibition of bacterial growth. A rat femoral condylar plug model was used to determine the effect of the graft, loaded with antibiotic, on bone healing.ResultsWe found that tobramycin loaded into a graft composed of bioglass and DBM eluted antibiotic above the minimum inhibitory concentration for three days in vitro. It was also found that the antibiotic loaded into the graft produced no adverse effects on the bone healing properties of the DBM at a lower level of antibiotic.ConclusionThis antibiotic-loaded bone void filler may represent a promising option for the delivery of local antibiotics in orthopaedic surgery. Cite this article: Bone Joint J 2016;98-B:1126–31. |
| Databáze: | OpenAIRE |
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