Adverse effects induced by chronic gamma irradiation in progeny of adult fish not affecting parental reproductive performance

Autor: Sophia Murat El Houdigui, Olivier Armant, Sandrine Frelon, Virginie Camilleri, Christelle Adam-Guillermin, Olivier Simon, Isabelle Cavalie, Patrice Gonzalez, Noémie Guirandy, Thomas Munch, Béatrice Gagnaire, Nicolas Dubourg, Caroline Arcanjo, Magali Floriani
Přispěvatelé: PSE-ENV/SRTE/LECO, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-SANTE/SDOS/LMDN, Centre National de la Recherche Scientifique (CNRS), Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Offspring
Health
Toxicology and Mutagenesis
media_common.quotation_subject
010501 environmental sciences
Biology
Ecotoxicology
01 natural sciences
irradiation exposure
reproduction
Andrology
03 medical and health sciences
Human fertilization
Animals
Environmental Chemistry
14. Life underwater
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0105 earth and related environmental sciences
media_common
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
chemistry.chemical_classification
0303 health sciences
Reactive oxygen species
Reproductive success
risk assessment
Dose-Response Relationship
Radiation
Embryo
Radiation Exposure
zebrafish
Fecundity
Survival Analysis
Oxidative Stress
Fertility
chemistry
Cesium Radioisotopes
Gamma Rays
Larva
[SDE]Environmental Sciences
Female
[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
Reproduction
DNA Damage
Mutagens
Zdroj: Environmental Toxicology and Chemistry
Environmental Toxicology and Chemistry, Wiley, 2019, 38 (11), pp.2556-2567. ⟨10.1002/etc.4562⟩
ISSN: 0730-7268
1552-8618
DOI: 10.1002/etc.4562⟩
Popis: Multigenerational studies have become of great interest in ecotoxicology since the consequence of parental exposure to contaminants on offspring generations was established in situ or in laboratory conditions. The present study mainly examined the chronic effects of external Cs-137 gamma irradiation exposure at 4 dose rates (control, 0.5, 5, and 50 mGy h-1 ) on adult zebrafish (F0) exposed for 10 d and their progeny (F1) exposed or unexposed for 4 to 5 d. The main endpoints investigated included parental reproductive performance, embryo-larval survival, DNA alterations, and reactive oxygen species (ROS) production in F0 and F1. No effects on reproductive success, fecundity, or egg fertilization rate were observed. However, drastic effects were observed on F1 exposed to 50 mGy h-1 , resulting in a mortality rate of 100%. The drastic effects were also observed when the progeny was not irradiated. It was demonstrated that the sensitivity of the embryos was mainly attributable to parental irradiation. Moreover, these drastic effects induced by adult irradiation disappeared over time when 10 d-irradiated adults were placed in a nonirradiated condition. Alterations in larval DNA were observed for the 3 dose rates, and an increase of ROS production was also shown for the 2 lowest dose rates. The present study improves our understanding of the consequences of parental exposure conditions to the progeny. Furthermore, it provides an incentive to take transmitted generational effects into account in ecological risk assessments. Environ Toxicol Chem 2019;38:2556-2567. © 2019 SETAC.
Databáze: OpenAIRE
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