Chemoradiation and granulocyte-colony or granulocyte macrophage-colony stimulating factors (G-CSF or GM-CSF): time to think out of the box?
| Autor: | Sandrine Sotton, Claire Bosacki, Elisabeth Daguenet, Alexis Vallard, Jean-Baptiste Guy, Marouan Benna, Omar Jmour, Oleksandr Ogorodniitchouk, Benoîte Méry, Saïd Soltani, Meiling Lan, Majed Ben Mrad, Nicolas Magné |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Review Article 03 medical and health sciences Mice 0302 clinical medicine Internal medicine Granulocyte Colony-Stimulating Factor medicine Combined Modality Therapy Animals Humans Radiology Nuclear Medicine and imaging Lung cancer Randomized Controlled Trials as Topic business.industry Granulocyte-Macrophage Colony-Stimulating Factor Combination chemotherapy General Medicine Immunotherapy Chemoradiotherapy Radioimmunotherapy medicine.disease Small Cell Lung Carcinoma Radiation therapy Clinical trial Disease Models Animal 030104 developmental biology Clinical Trials Phase III as Topic 030220 oncology & carcinogenesis Concomitant business |
| Zdroj: | Br J Radiol |
| ISSN: | 1748-880X |
| Popis: | Concerns have been raised about potential toxic interactions when colony-stimulating factors (CSFs) and chemoradiation are concurrently performed. In 2006, the ASCO guidelines advised against their concomitant use. Nevertheless, with the development of modern radiotherapy techniques and supportive care, the therapeutic index of combined chemotherapy, radiotherapy, and CSFs is worth reassessing. Recent clinical trials testing chemoradiation in lung cancer let investigators free to decide the use of concomitant CSFs or not. No abnormal infield event was reported after the use of modern radiotherapy techniques and concomitant chemotherapy regimens. These elements call for further investigation to set new recommendations in favour of the association of chemoradiation and CSFs. Moreover, radiotherapy could induce anticancer systemic effects mediated by the immune system in vitro and in vivo. With combined CSFs, this effect was reinforced in preclinical and clinical trials introducing innovative radioimmunotherapy models. So far, the association of radiation with CSFs has not been combined with immunotherapy. However, it might play a major role in triggering an immune response against cancer cells, leading to abscopal effects. The present article reassesses the therapeutic index of the combination CSFs-chemoradiation through an updated review on its safety and efficacy. It also provides a special focus on radioimmunotherapy. |
| Databáze: | OpenAIRE |
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