Computational Analysis Identifies Novel Biomarkers for High-Risk Bladder Cancer Patients
| Autor: | Radosław Piliszek, Anna A. Brożyna, Witold R. Rudnicki |
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| Rok vydání: | 2022 |
| Předmět: |
Organic Chemistry
Urinary Bladder General Medicine Catalysis Computer Science Applications Inorganic Chemistry nonmuscle-invasive bladder cancer (NMIBC) carcinoma in situ (CIS) biomarker identification optimal feature set selection Urinary Bladder Neoplasms Biomarkers Tumor Disease Progression Humans Neoplasm Invasiveness Physical and Theoretical Chemistry Molecular Biology Spectroscopy Biomarkers Carcinoma in Situ |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7057 |
| ISSN: | 1422-0067 |
| Popis: | In the case of bladder cancer, carcinoma in situ (CIS) is known to have poor diagnosis. However, there are not enough studies that examine the biomarkers relevant to CIS development. Omics experiments generate data with tens of thousands of descriptive variables, e.g., gene expression levels. Often, many of these descriptive variables are identified as somehow relevant, resulting in hundreds or thousands of relevant variables for building models or for further data analysis. We analyze one such dataset describing patients with bladder cancer, mostly non-muscle-invasive (NMIBC), and propose a novel approach to feature selection. This approach returns high-quality features for prediction and yet allows interpretability as well as a certain level of insight into the analyzed data. As a result, we obtain a small set of seven of the most-useful biomarkers for diagnostics. They can also be used to build tests that avoid the costly and time-consuming existing methods. We summarize the current biological knowledge of the chosen biomarkers and contrast it with our findings. |
| Databáze: | OpenAIRE |
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