Within-Host Diversity and Vertical Transmission of Group B Streptococcus Among Mother-infant Dyads in The Gambia
| Autor: | Fatima Ceesay, Martin Ota, Brenda Kwambana-Adams, Martin Antonio, Archibald Worwui, Madikay Senghore, Mark J. Pallen, James Jafali, Sainabou Bojang, Nabil-Fareed Alikhan, Amara Jah, Kaddijatou Jawneh, Anuradha Ravi, Aderonke Odutola, Ebenezer Foster-Nyarko, Ezra O. Ogundare, Maimuna Jarju |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Mother to child transmission business.industry Transmission (medicine) Streptococcus Obstetrics Mother infant medicine.disease_cause bacterial infections and mycoses Group B 3. Good health Colonisation 03 medical and health sciences 0302 clinical medicine Medicine bacteria 030212 general & internal medicine Significant risk business human activities reproductive and urinary physiology 030304 developmental biology |
| DOI: | 10.1101/760512 |
| Popis: | IntroductionUnderstanding mother-to-infant transmission of Group B Streptococcus (GBS) is vital to the prevention and control of GBS disease. We investigated the transmission and phylogenetic relationships of mothers colonised by GBS and their infants in a peri-urban setting in The Gambia.MethodsWe collected nasopharyngeal swabs from 35 mother-infant dyads at weekly intervals from birth until six weeks post-partum. GBS was isolated by conventional microbiology techniques. Whole-genome sequencing was performed on GBS isolates from one mother-infant dyad (dyad 17).ResultsWe recovered 85 GBS isolates from the 245 nasopharyngeal swabs. GBS was isolated from 16.33% and 18.37% of sampled mothers and infants, respectively. In 87% of cultured swabs, the culture status of an infant agreed with that of the mother (Kappa p-value ConclusionGBS colonisation in mothers presents a significant risk of colonisation in their infants. We confirm vertical transmission from mother to child in dyad 17, accompanied by within-host diversity. |
| Databáze: | OpenAIRE |
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