The association of PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms with T1D in Egyptian children
| Autor: | Doaa M. Abd Elrahman, Laila M. Sherief, Hadeel M. Abdelrahman, Hosam F. Elsaadani, Randa H. Mohamed, Ashgan A. Alghobashy |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Adolescent Genotype endocrine system diseases Immunology Polymorphism Single Nucleotide law.invention PTPN22 03 medical and health sciences Sex Factors 0302 clinical medicine Gene Frequency immune system diseases law Diabetes mellitus medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Child Genetic Association Studies Polymerase chain reaction Early onset Autoimmune disease Type 1 diabetes business.industry Interleukin-2 Receptor alpha Subunit Protein Tyrosine Phosphatase Non-Receptor Type 22 General Medicine medicine.disease Diabetes Mellitus Type 1 030104 developmental biology Egypt Female business 030215 immunology |
| Zdroj: | Human Immunology. 77:682-686 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2016.06.006 |
| Popis: | Background Type 1 diabetes mellitus (T1D) is a T cell-mediated autoimmune disease characterized by the destruction of pancreatic β cells. PTPN22 and IL2RA polymorphisms have been found to be associated with several autoimmune diseases including T1D. Aims We aimed to elucidate the role of PTPN22 and IL2RA polymorphisms in predisposition of T1D in Egyptian children. Methods We studied 150 children and adolescents with T1D and 165 healthy controls. The PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms were genotyped using polymerase chain reaction. Results We found that carriers of the T allele of PTPN22 were significantly more likely to develop T1D (OR = 2.2, 95% CI = 1.2–4, P = 0.01). Also, the carrier of TT genotype and T allele of IL2RA more likely to develop T1D (OR = 2.8, 1.4, respectively, P = 0.03). There was a statistically significant association between T allele of PTPN22 gene and females ⩽10 years old at the onset of diabetes (OR = 4, 95% CI = 1.2–13.4, P = 0.019). Conclusion This study suggests a possible association between the T allele of PTPN22 gene and TT genotype of IL2RA with T1D in studied Egyptian children, especially, females with early onset diabetes who carried the 1858T allele. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect