Gene polymorphism of 3'APO-VNTR in Egyptians with coronary artery disease
| Autor: | Rehab Elmougy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B dislipidemija Clinical Biochemistry CAD Apo B Coronary artery disease Internal medicine Genotype medicine genetics Risk factor Original Paper biology business.industry koronarno arterijsko oboljenje Biochemistry (medical) dyslipidemia medicine.disease PCR genetika biology.protein Gene polymorphism Artery diseases business Dyslipidemia coronary artery disease |
| Zdroj: | Journal of Medical Biochemistry |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | Coronary artery diseases (CAD) are big health problem in both developed and developing countries. It is considered one of the main causes of death in the world. Dyslipidemia increases the risk of CAD incidences. It is aimed in this worktop study the impact of 3'APOBVNTRgene on CAD incidences.Eighty CAD patients and ninety-three healthy volunteers are enrolled in this study. Lipid parameters were estimated in both groups and PCR technique has been performed to analyze 3'APOB-VNTR gene polymorphism.The genotypes 31/31, 31/37, 37/37 and 31/44 are more predominant in both groups. The frequency of 24/31 in CAD patients is (0.137) while it is completely absent in the control group. Our results show that there is an increase in the frequency of various genotypes (e.g., 17/31 and 21/34 genotypes) in the control group compared to theca patients group.3'APOB-VNTR gene could probably be considered a risk factor for CAD incidences and may help to early diagnose them.Koronarno arterijsko oboljenje (CAD) je veliki zdravstveni problem kako u razvijenim tako i u nerazvijenim zemljama. Smatra se da je jedan od glavnih uzroka smrtnosti u svetu. Dislipidemija povećava rizik od učestalosti CAD. Cilj ovog rada je bio ispitivanje uticaja 3'APOB-VNTR gena na učestalost CAD.Ovo poučavanje obuhvatilo je osamdeset CAD pacijenata i devedeset tri zdrava volontera. U obe grupe određivani su lipidni parametri a primenom PCR tehnike analiziran je genetski polimorfizam 3'-APOB-VNTR.U obe grupe bili su predominantni geni 31/31, 31/37, 37/37 i 31/44. Učestalost 24/31 u CAD pacijenata je bila 0,137, dok je u potpunosti izostala kod kontrolne grupe. Naši rezultati pokazuju da postoji povećanje u učestalosti različitih genotipova (npr. 17/31 i 21/34) u kontrolnoj grupi u poređenju sa grupom pacijenata.3'APOB-VNTR GEN može se najverovatnije smatrati kao faktor rizika za učestalost CAD i može se koristiti za ranu dijagnozu. |
| Databáze: | OpenAIRE |
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