Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies

Autor: Lukas Smolej, Pavlína Králíčková, Monika Motyčková, Jan Krejsek, Pavel Zak, Eva Malá, Ondrej Soucek, Vojtěch Thon, Martin Simkovic, J. Kuhnova, Pavel Vodárek, Ctirad Andrys
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Immunoglobulin levels
0302 clinical medicine
Immunology and Allergy
Medicine
Immunodeficiency
chemistry.chemical_classification
Aged
80 and over
biology
Healthy population
General Medicine
Middle Aged
Prognosis
Antibodies
Bacterial
3. Good health
Streptococcus pneumoniae
030220 oncology & carcinogenesis
Female
Antibody
Research Article
lcsh:Immunologic diseases. Allergy
Adult
Article Subject
Adolescent
Immunology
Alpha (ethology)
Galactosylceramides
Polysaccharide
Pneumococcal Infections
03 medical and health sciences
Young Adult
Humans
In patient
Bacterial Capsules
Aged
Autoantibodies
business.industry
Common variable immunodeficiency
medicine.disease
Immunity
Humoral
Immunoglobulin A
Common Variable Immunodeficiency
chemistry
Immunoglobulin M
Immunoglobulin G
biology.protein
business
lcsh:RC581-607
Biomarkers
030215 immunology
Zdroj: Journal of Immunology Research
Journal of Immunology Research, Vol 2017 (2017)
ISSN: 2314-7156
2314-8861
Popis: Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients with common variable immunodeficiency (CVID), and (3) a healthy population and to explore their diagnostic and prognostic potential. Serum immunoglobulin levels and levels of anti-Gal IgG, IgA, and IgM and anti-PCP IgG and IgG2 were determined in 59 CLL patients, 30 CVID patients, and 67 healthy controls. Levels of IgG, IgA, IgM, anti-Gal IgA, anti-Gal IgM, and anti-PCP IgA were lower in CLL and CVID patients than in healthy controls (p value for all parameters
Databáze: OpenAIRE
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