N-methyl-D-aspartate stimulates dopamine release through nitric oxide formation in the nucleus accumbens of rats
| Autor: | Ikumi Arai, Masuo Ohno, Shigenori Watanabe |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis N-Methylaspartate Dopamine Nucleus accumbens Arginine Nitric Oxide Nucleus Accumbens chemistry.chemical_compound Dopamine receptor D1 Internal medicine Basal ganglia medicine Animals Rats Wistar Neurotransmitter Molecular Biology Dose-Response Relationship Drug General Neuroscience Rats Endocrinology nervous system chemistry Catecholamine NMDA receptor Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain research. 699(2) |
| ISSN: | 0006-8993 |
| Popis: | Intracerebral microdialysis technique was utilized to study the effect of NG-nitro-L-arginine, a nitric oxide (NO) synthase inhibitor, on N-methyl-D-aspartate (NMDA)-induced dopamine overflow in the nucleus accumbens of unanesthetized, freely moving rats. Perfusion of 1 and 3 mM NMDA through the microdialysis probe dose-dependently increased the extracellular dopamine level in the nucleus accumbens. Coapplication of 0.5 mM D-(-)-2-amino-5-phosphonovaleric acid (D-AP5), a selective and competitive NMDA receptor antagonist, significantly reduced the dopamine overflow induced by 3 mM NMDA. Perfusion of 0.5 mM NG-nitro-L-arginine alone did not affect the basal dopamine level, whereas it suppressed the NMDA-evoked dopamine overflow in the nucleus accumbens when concurrently applied with 3 mM NMDA. These results suggest that NO mediates, at least in part, dopamine release resulting from NMDA receptor activation in the nucleus accumbens of rats. |
| Databáze: | OpenAIRE |
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